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502 results
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Radicals r'aging.
Wallace DC, Melov S. Wallace DC, et al. Nat Genet. 1998 Jun;19(2):105-6. doi: 10.1038/448. Nat Genet. 1998. PMID: 9620757 No abstract available.
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster.
Tong JJ, Schriner SE, McCleary D, Day BJ, Wallace DC. Tong JJ, et al. Among authors: wallace dc. Nat Genet. 2007 Apr;39(4):476-85. doi: 10.1038/ng2004. Epub 2007 Mar 18. Nat Genet. 2007. PMID: 17369827
Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA.
Melov S, Schneider JA, Coskun PE, Bennett DA, Wallace DC. Melov S, et al. Among authors: wallace dc. Neurobiol Aging. 1999 Sep-Oct;20(5):565-71. doi: 10.1016/s0197-4580(99)00092-5. Neurobiol Aging. 1999. PMID: 10638530
The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations.
Loeb LA, Wallace DC, Martin GM. Loeb LA, et al. Among authors: wallace dc. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18769-70. doi: 10.1073/pnas.0509776102. Epub 2005 Dec 19. Proc Natl Acad Sci U S A. 2005. PMID: 16365283 Free PMC article. No abstract available.
Extension of life-span with superoxide dismutase/catalase mimetics.
Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ. Melov S, et al. Among authors: wallace dc. Science. 2000 Sep 1;289(5484):1567-9. doi: 10.1126/science.289.5484.1567. Science. 2000. PMID: 10968795
Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis.
Kokoszka JE, Coskun P, Esposito LA, Wallace DC. Kokoszka JE, et al. Among authors: wallace dc. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2278-83. doi: 10.1073/pnas.051627098. Epub 2001 Feb 13. Proc Natl Acad Sci U S A. 2001. PMID: 11226230 Free PMC article.
Mitochondria and cancer.
Wallace DC. Wallace DC. Nat Rev Cancer. 2012 Oct;12(10):685-98. doi: 10.1038/nrc3365. Nat Rev Cancer. 2012. PMID: 23001348 Free PMC article. Review.
Extension of murine life span by overexpression of catalase targeted to mitochondria.
Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS. Schriner SE, et al. Among authors: wallace dc. Science. 2005 Jun 24;308(5730):1909-11. doi: 10.1126/science.1106653. Epub 2005 May 5. Science. 2005. PMID: 15879174
Lactate Limits T Cell Proliferation via the NAD(H) Redox State.
Quinn WJ 3rd, Jiao J, TeSlaa T, Stadanlick J, Wang Z, Wang L, Akimova T, Angelin A, Schäfer PM, Cully MD, Perry C, Kopinski PK, Guo L, Blair IA, Ghanem LR, Leibowitz MS, Hancock WW, Moon EK, Levine MH, Eruslanov EB, Wallace DC, Baur JA, Beier UH. Quinn WJ 3rd, et al. Among authors: wallace dc. Cell Rep. 2020 Dec 15;33(11):108500. doi: 10.1016/j.celrep.2020.108500. Cell Rep. 2020. PMID: 33326785 Free article.
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Aras S, Purandare N, Gladyck S, Somayajulu-Nitu M, Zhang K, Wallace DC, Grossman LI. Aras S, et al. Among authors: wallace dc. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32056-32065. doi: 10.1073/pnas.2005877117. Epub 2020 Nov 30. Proc Natl Acad Sci U S A. 2020. PMID: 33257573
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