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16 results
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Tetrahydroquinoline-based selective estrogen receptor modulators (SERMs).
Wallace OB, Lauwers KS, Jones SA, Dodge JA. Wallace OB, et al. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1907-10. doi: 10.1016/s0960-894x(03)00306-8. Bioorg Med Chem Lett. 2003. PMID: 12749895
A survey of core replacements in indole-based HIV-1 attachment inhibitors.
Wang T, Wallace OB, Zhang Z, Fang H, Yang Z, Robinson BA, Spicer TP, Gong YF, Blair WS, Shi PY, Lin PF, Deshpande M, Meanwell NA, Kadow JF. Wang T, et al. Among authors: wallace ob. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1423-1429. doi: 10.1016/j.bmcl.2019.03.018. Epub 2019 Mar 28. Bioorg Med Chem Lett. 2019. PMID: 30940396
Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.
Richardson TI, Frank SA, Wang M, Clarke CA, Jones SA, Ying BP, Kohlman DT, Wallace OB, Shepherd TA, Dally RD, Palkowitz AD, Geiser AG, Bryant HU, Henck JW, Cohen IR, Rudmann DG, McCann DJ, Coutant DE, Oldham SW, Hummel CW, Fong KC, Hinklin R, Lewis G, Tian H, Dodge JA. Richardson TI, et al. Among authors: wallace ob. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3544-9. doi: 10.1016/j.bmcl.2007.04.044. Epub 2007 Apr 24. Bioorg Med Chem Lett. 2007. PMID: 17482463
Benzothiophene and naphthalene derived constrained SERMs.
Wallace OB, Bryant HU, Shetler PK, Adrian MD, Geiser AG. Wallace OB, et al. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5103-6. doi: 10.1016/j.bmcl.2004.07.072. Bioorg Med Chem Lett. 2004. PMID: 15380208
A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation.
Geiser AG, Hummel CW, Draper MW, Henck JW, Cohen IR, Rudmann DG, Donnelly KB, Adrian MD, Shepherd TA, Wallace OB, McCann DJ, Oldham SW, Bryant HU, Sato M, Dodge JA. Geiser AG, et al. Among authors: wallace ob. Endocrinology. 2005 Oct;146(10):4524-35. doi: 10.1210/en.2005-0024. Epub 2005 Jul 7. Endocrinology. 2005. PMID: 16002528
Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity.
Meanwell NA, Wallace OB, Wang H, Deshpande M, Pearce BC, Trehan A, Yeung KS, Qiu Z, Wright JJ, Robinson BA, Gong YF, Wang HG, Spicer TP, Blair WS, Shi PY, Lin PF. Meanwell NA, et al. Among authors: wallace ob. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5136-9. doi: 10.1016/j.bmcl.2009.07.027. Epub 2009 Jul 10. Bioorg Med Chem Lett. 2009. PMID: 19632112
Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns.
Meanwell NA, Wallace OB, Fang H, Wang H, Deshpande M, Wang T, Yin Z, Zhang Z, Pearce BC, James J, Yeung KS, Qiu Z, Kim Wright JJ, Yang Z, Zadjura L, Tweedie DL, Yeola S, Zhao F, Ranadive S, Robinson BA, Gong YF, Wang HG, Spicer TP, Blair WS, Shi PY, Colonno RJ, Lin PF. Meanwell NA, et al. Among authors: wallace ob. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1977-81. doi: 10.1016/j.bmcl.2009.02.040. Epub 2009 Feb 13. Bioorg Med Chem Lett. 2009. PMID: 19251416
N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.
Parker MF, Barten DM, Bergstrom CP, Bronson JJ, Corsa JA, Deshpande MS, Felsenstein KM, Guss VL, Hansel SB, Johnson G, Keavy DJ, Lau WY, Mock J, Prasad CV, Polson CT, Sloan CP, Smith DW, Wallace OB, Wang HH, Williams A, Zheng M. Parker MF, et al. Among authors: wallace ob. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4432-6. doi: 10.1016/j.bmcl.2007.06.022. Epub 2007 Jun 10. Bioorg Med Chem Lett. 2007. PMID: 17606371
A selective estrogen receptor modulator for the treatment of hot flushes.
Wallace OB, Lauwers KS, Dodge JA, May SA, Calvin JR, Hinklin R, Bryant HU, Shetler PK, Adrian MD, Geiser AG, Sato M, Burris TP. Wallace OB, et al. J Med Chem. 2006 Feb 9;49(3):843-6. doi: 10.1021/jm0509795. J Med Chem. 2006. PMID: 16451049
A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.
Hummel CW, Geiser AG, Bryant HU, Cohen IR, Dally RD, Fong KC, Frank SA, Hinklin R, Jones SA, Lewis G, McCann DJ, Rudmann DG, Shepherd TA, Tian H, Wallace OB, Wang M, Wang Y, Dodge JA. Hummel CW, et al. Among authors: wallace ob. J Med Chem. 2005 Nov 3;48(22):6772-5. doi: 10.1021/jm050723z. J Med Chem. 2005. PMID: 16250633
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