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MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
Malinin NL, Boldin MP, Kovalenko AV, Wallach D. Malinin NL, et al. Nature. 1997 Feb 6;385(6616):540-4. doi: 10.1038/385540a0. Nature. 1997. PMID: 9020361
Dominant negative MORT1/FADD rescues mice from CD95 and TNF-induced liver failure.
Schuchmann M, Varfolomeev EE, Hermann F, Rueckert F, Strand D, Koehler H, Strand S, Lohse AW, Wallach D, Galle PR. Schuchmann M, et al. Hepatology. 2003 Jan;37(1):129-35. doi: 10.1053/jhep.2003.50011. Hepatology. 2003. PMID: 12500197
Up the down staircase.
Wallach D. Wallach D. Nat Immunol. 2002 Sep;3(9):802-3. doi: 10.1038/ni0902-802. Nat Immunol. 2002. PMID: 12205467 No abstract available.
Self-termination of the terminator.
Wallach D, Kovalenko A. Wallach D, et al. Nat Immunol. 2008 Dec;9(12):1325-7. doi: 10.1038/ni1208-1325. Nat Immunol. 2008. PMID: 19008929 No abstract available.
NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity.
Sánchez-Valdepeñas C, Martín AG, Ramakrishnan P, Wallach D, Fresno M. Sánchez-Valdepeñas C, et al. J Immunol. 2006 Apr 15;176(8):4666-74. doi: 10.4049/jimmunol.176.8.4666. J Immunol. 2006. PMID: 16585559
Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice.
Kang TB, Oh GS, Scandella E, Bolinger B, Ludewig B, Kovalenko A, Wallach D. Kang TB, et al. J Immunol. 2008 Aug 15;181(4):2522-32. doi: 10.4049/jimmunol.181.4.2522. J Immunol. 2008. PMID: 18684943
Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.
Li Y, Kang J, Friedman J, Tarassishin L, Ye J, Kovalenko A, Wallach D, Horwitz MS. Li Y, et al. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1042-7. doi: 10.1073/pnas.96.3.1042. Proc Natl Acad Sci U S A. 1999. PMID: 9927690 Free PMC article.
Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta.
Sylla BS, Hung SC, Davidson DM, Hatzivassiliou E, Malinin NL, Wallach D, Gilmore TD, Kieff E, Mosialos G. Sylla BS, et al. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10106-11. doi: 10.1073/pnas.95.17.10106. Proc Natl Acad Sci U S A. 1998. PMID: 9707608 Free PMC article.
TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways.
Carpentier I, Declercq W, Malinin NL, Wallach D, Fiers W, Beyaert R. Carpentier I, et al. FEBS Lett. 1998 Mar 27;425(2):195-8. doi: 10.1016/s0014-5793(98)00226-9. FEBS Lett. 1998. PMID: 9559646
CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase.
Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K. Akiba H, et al. J Biol Chem. 1998 May 22;273(21):13353-8. doi: 10.1074/jbc.273.21.13353. J Biol Chem. 1998. PMID: 9582383
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