Wallweber HJ - Search Results

1

Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.

Ferrao RD, Wallweber HJ, Lupardus PJ. Ferrao RD, et al. Among authors: wallweber hj. Elife. 2018 Jul 25;7:e38089. doi: 10.7554/eLife.38089. Elife. 2018. PMID: 30044226 Free PMC article.

2

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.

Wang X, Magnuson S, Pastor R, Fan E, Hu H, Tsui V, Deng W, Murray J, Steffek M, Wallweber H, Moffat J, Drummond J, Chan G, Harstad E, Ebens AJ. Wang X, et al. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3149-53. doi: 10.1016/j.bmcl.2013.04.020. Epub 2013 Apr 17. Bioorg Med Chem Lett. 2013. PMID: 23623490

3

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.

Lupardus PJ, Ultsch M, Wallweber H, Bir Kohli P, Johnson AR, Eigenbrot C. Lupardus PJ, et al. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8025-30. doi: 10.1073/pnas.1401180111. Epub 2014 May 19. Proc Natl Acad Sci U S A. 2014. PMID: 24843152 Free PMC article.

4

Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptD.

Storek KM, Chan J, Vij R, Chiang N, Lin Z, Bevers J 3rd, Koth CM, Vernes JM, Meng YG, Yin J, Wallweber H, Dalmas O, Shriver S, Tam C, Schneider K, Seshasayee D, Nakamura G, Smith PA, Payandeh J, Koerber JT, Comps-Agrar L, Rutherford ST. Storek KM, et al. Elife. 2019 Jun 25;8:e46258. doi: 10.7554/eLife.46258. Elife. 2019. PMID: 31237236 Free PMC article.

5

Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.

Lee CV, Hymowitz SG, Wallweber HJ, Gordon NC, Billeci KL, Tsai SP, Compaan DM, Yin J, Gong Q, Kelley RF, DeForge LE, Martin F, Starovasnik MA, Fuh G. Lee CV, et al. Among authors: wallweber hj. Blood. 2006 Nov 1;108(9):3103-11. doi: 10.1182/blood-2006-03-011031. Epub 2006 Jul 13. Blood. 2006. PMID: 16840730 Free article.

6

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2.

Wallweber HJ, Tam C, Franke Y, Starovasnik MA, Lupardus PJ. Wallweber HJ, et al. Nat Struct Mol Biol. 2014 May;21(5):443-8. doi: 10.1038/nsmb.2807. Epub 2014 Apr 6. Nat Struct Mol Biol. 2014. PMID: 24704786 Free PMC article.

7

The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.

de Leon-Boenig G, Bowman KK, Feng JA, Crawford T, Everett C, Franke Y, Oh A, Stanley M, Staben ST, Starovasnik MA, Wallweber HJ, Wu J, Wu LC, Johnson AR, Hymowitz SG. de Leon-Boenig G, et al. Among authors: wallweber hj. Structure. 2012 Oct 10;20(10):1704-14. doi: 10.1016/j.str.2012.07.013. Epub 2012 Aug 23. Structure. 2012. PMID: 22921830 Free article.

8

Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display.

Gordon NC, Lien S, Johnson J, Wallweber HJ, Tran T, Currell B, Mathieu M, Quan C, Starovasnik MA, Hymowitz SG, Kelley RF. Gordon NC, et al. Among authors: wallweber hj. J Mol Biol. 2010 Feb 12;396(1):166-77. doi: 10.1016/j.jmb.2009.11.041. Epub 2009 Nov 26. J Mol Biol. 2010. PMID: 19945466

9

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Zobel K, et al. Among authors: wallweber hj. ACS Chem Biol. 2006 Sep 19;1(8):525-33. doi: 10.1021/cb600276q. ACS Chem Biol. 2006. PMID: 17168540

10

Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.

Hymowitz SG, Patel DR, Wallweber HJ, Runyon S, Yan M, Yin J, Shriver SK, Gordon NC, Pan B, Skelton NJ, Kelley RF, Starovasnik MA. Hymowitz SG, et al. Among authors: wallweber hj. J Biol Chem. 2005 Feb 25;280(8):7218-27. doi: 10.1074/jbc.M411714200. Epub 2004 Nov 12. J Biol Chem. 2005. PMID: 15542592 Free article.

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