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The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation.
Walter AO, Seghezzi W, Korver W, Sheung J, Lees E. Walter AO, et al. Oncogene. 2000 Oct 5;19(42):4906-16. doi: 10.1038/sj.onc.1203847. Oncogene. 2000. PMID: 11039908 Free article.
The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism.
Walter AO, Peng ZY, Cartwright CA. Walter AO, et al. Oncogene. 1999 Mar 18;18(11):1911-20. doi: 10.1038/sj.onc.1202513. Oncogene. 1999. PMID: 10208413
Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells.
Charych DH, Coyne M, Yabannavar A, Narberes J, Chow S, Wallroth M, Shafer C, Walter AO. Charych DH, et al. Among authors: walter ao. J Cell Biochem. 2008 Jun 1;104(3):1075-86. doi: 10.1002/jcb.21698. J Cell Biochem. 2008. PMID: 18286467
4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors.
Shafer CM, Lindvall M, Bellamacina C, Gesner TG, Yabannavar A, Jia W, Lin S, Walter A. Shafer CM, et al. Among authors: walter a. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4482-5. doi: 10.1016/j.bmcl.2008.07.061. Epub 2008 Jul 17. Bioorg Med Chem Lett. 2008. PMID: 18672368
3D Pharmacophore Model-Assisted Discovery of Novel CDC7 Inhibitors.
Lindvall M, McBride C, McKenna M, Gesner TG, Yabannavar A, Wong K, Lin S, Walter A, Shafer CM. Lindvall M, et al. Among authors: walter a. ACS Med Chem Lett. 2011 Aug 2;2(10):720-3. doi: 10.1021/ml200029w. eCollection 2011 Oct 13. ACS Med Chem Lett. 2011. PMID: 24900258 Free PMC article.
The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
Barsanti PA, Wang W, Ni ZJ, Duhl D, Brammeier N, Martin E, Bussiere D, Walter AO. Barsanti PA, et al. Among authors: walter ao. Bioorg Med Chem Lett. 2010 Jan 1;20(1):157-60. doi: 10.1016/j.bmcl.2009.11.012. Epub 2009 Nov 12. Bioorg Med Chem Lett. 2010. PMID: 19945875
Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.
Walter AO, Sjin RT, Haringsma HJ, Ohashi K, Sun J, Lee K, Dubrovskiy A, Labenski M, Zhu Z, Wang Z, Sheets M, St Martin T, Karp R, van Kalken D, Chaturvedi P, Niu D, Nacht M, Petter RC, Westlin W, Lin K, Jaw-Tsai S, Raponi M, Van Dyke T, Etter J, Weaver Z, Pao W, Singh J, Simmons AD, Harding TC, Allen A. Walter AO, et al. Cancer Discov. 2013 Dec;3(12):1404-15. doi: 10.1158/2159-8290.CD-13-0314. Epub 2013 Sep 24. Cancer Discov. 2013. PMID: 24065731 Free PMC article.
Phase I dose-escalation studies of roniciclib, a pan-cyclin-dependent kinase inhibitor, in advanced malignancies.
Bahleda R, Grilley-Olson JE, Govindan R, Barlesi F, Greillier L, Perol M, Ray-Coquard I, Strumberg D, Schultheis B, Dy GK, Zalcman G, Weiss GJ, Walter AO, Kornacker M, Rajagopalan P, Henderson D, Nogai H, Ocker M, Soria JC. Bahleda R, et al. Among authors: walter ao. Br J Cancer. 2017 Jun 6;116(12):1505-1512. doi: 10.1038/bjc.2017.92. Epub 2017 May 2. Br J Cancer. 2017. PMID: 28463960 Free PMC article. Clinical Trial.
First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity.
Postel-Vinay S, Herbschleb K, Massard C, Woodcock V, Soria JC, Walter AO, Ewerton F, Poelman M, Benson N, Ocker M, Wilkinson G, Middleton M. Postel-Vinay S, et al. Among authors: walter ao. Eur J Cancer. 2019 Mar;109:103-110. doi: 10.1016/j.ejca.2018.12.020. Epub 2019 Jan 31. Eur J Cancer. 2019. PMID: 30711772 Clinical Trial.
In vitro and in vivo characterization of irreversible mutant-selective EGFR inhibitors that are wild-type sparing.
Tjin Tham Sjin R, Lee K, Walter AO, Dubrovskiy A, Sheets M, Martin TS, Labenski MT, Zhu Z, Tester R, Karp R, Medikonda A, Chaturvedi P, Ren Y, Haringsma H, Etter J, Raponi M, Simmons AD, Harding TC, Niu D, Nacht M, Westlin WF, Petter RC, Allen A, Singh J. Tjin Tham Sjin R, et al. Among authors: walter ao. Mol Cancer Ther. 2014 Jun;13(6):1468-79. doi: 10.1158/1535-7163.MCT-13-0966. Epub 2014 Apr 10. Mol Cancer Ther. 2014. PMID: 24723450 Free article.
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