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91 results
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Chemistry: Chemical con artists foil drug discovery.
Baell J, Walters MA. Baell J, et al. Among authors: walters ma. Nature. 2014 Sep 25;513(7519):481-3. doi: 10.1038/513481a. Nature. 2014. PMID: 25254460 No abstract available.
Mitigating risk in academic preclinical drug discovery.
Dahlin JL, Inglese J, Walters MA. Dahlin JL, et al. Among authors: walters ma. Nat Rev Drug Discov. 2015 Apr;14(4):279-94. doi: 10.1038/nrd4578. Nat Rev Drug Discov. 2015. PMID: 25829283 Free PMC article. Review.
Nuisance compounds in cellular assays.
Dahlin JL, Auld DS, Rothenaigner I, Haney S, Sexton JZ, Nissink JWM, Walsh J, Lee JA, Strelow JM, Willard FS, Ferrins L, Baell JB, Walters MA, Hua BK, Hadian K, Wagner BK. Dahlin JL, et al. Among authors: walters ma. Cell Chem Biol. 2021 Mar 18;28(3):356-370. doi: 10.1016/j.chembiol.2021.01.021. Epub 2021 Feb 15. Cell Chem Biol. 2021. PMID: 33592188 Review.
The promise and peril of chemical probes.
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ. Arrowsmith CH, et al. Among authors: walters ma. Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. Nat Chem Biol. 2015. PMID: 26196764 Free PMC article.
Risk Management in Early Discovery Medicinal Chemistry.
Singh G, Dahlin JL, Walters MA. Singh G, et al. Among authors: walters ma. Methods Enzymol. 2018;610:1-25. doi: 10.1016/bs.mie.2018.09.012. Epub 2018 Oct 19. Methods Enzymol. 2018. PMID: 30390795
How to Triage PAINS-Full Research.
Dahlin JL, Walters MA. Dahlin JL, et al. Among authors: walters ma. Assay Drug Dev Technol. 2016 Apr;14(3):168-74. doi: 10.1089/adt.2015.674. Epub 2015 Oct 23. Assay Drug Dev Technol. 2016. PMID: 26496388 Free PMC article.
Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.
Shrimp JH, Jing Y, Gamage ST, Nelson KM, Han J, Bryson KM, Montgomery DC, Thomas JM, Nance KD, Sharma S, Fox SD, Andressen T, Sinclair WR, Wu H, Allali-Hassani A, Senisterra G, Vedadi M, Lafontaine D, Dahlin JL, Marmorstein R, Walters MA, Meier JL. Shrimp JH, et al. Among authors: walters ma. ACS Med Chem Lett. 2020 Jul 27;12(6):887-892. doi: 10.1021/acsmedchemlett.0c00193. eCollection 2021 Jun 10. ACS Med Chem Lett. 2020. PMID: 34141066
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