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Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands.
Harrison CA, Al-Musawi SL, Walton KL. Harrison CA, et al. Among authors: walton kl. Growth Factors. 2011 Oct;29(5):174-86. doi: 10.3109/08977194.2011.608666. Epub 2011 Aug 24. Growth Factors. 2011. PMID: 21864080
Suppression of inhibin A biological activity by alterations in the binding site for betaglycan.
Makanji Y, Walton KL, Wilce MC, Chan KL, Robertson DM, Harrison CA. Makanji Y, et al. Among authors: walton kl. J Biol Chem. 2008 Jun 13;283(24):16743-51. doi: 10.1074/jbc.M801045200. Epub 2008 Apr 7. J Biol Chem. 2008. PMID: 18397882
A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGFbeta) ligands.
Walton KL, Makanji Y, Wilce MC, Chan KL, Robertson DM, Harrison CA. Walton KL, et al. J Biol Chem. 2009 Apr 3;284(14):9311-20. doi: 10.1074/jbc.M808763200. Epub 2009 Feb 3. J Biol Chem. 2009. PMID: 19193648 Free PMC article.
Inhibin B is a more potent suppressor of rat follicle-stimulating hormone release than inhibin a in vitro and in vivo.
Makanji Y, Temple-Smith PD, Walton KL, Harrison CA, Robertson DM. Makanji Y, et al. Among authors: walton kl. Endocrinology. 2009 Oct;150(10):4784-93. doi: 10.1210/en.2008-1783. Epub 2009 Jul 9. Endocrinology. 2009. PMID: 19589860
Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex.
Walton KL, Makanji Y, Chen J, Wilce MC, Chan KL, Robertson DM, Harrison CA. Walton KL, et al. J Biol Chem. 2010 May 28;285(22):17029-37. doi: 10.1074/jbc.M110.110288. Epub 2010 Mar 22. J Biol Chem. 2010. PMID: 20308061 Free PMC article.
The synthesis and secretion of inhibins.
Walton KL, Makanji Y, Robertson DM, Harrison CA. Walton KL, et al. Vitam Horm. 2011;85:149-84. doi: 10.1016/B978-0-12-385961-7.00008-1. Vitam Horm. 2011. PMID: 21353880 Review.
Generation of a specific activin antagonist by modification of the activin A propeptide.
Makanji Y, Walton KL, Chan KL, Gregorevic P, Robertson DM, Harrison CA. Makanji Y, et al. Among authors: walton kl. Endocrinology. 2011 Oct;152(10):3758-68. doi: 10.1210/en.2011-1052. Epub 2011 Jul 12. Endocrinology. 2011. PMID: 21750050
New insights into the mechanisms of activin action and inhibition.
Walton KL, Makanji Y, Harrison CA. Walton KL, et al. Mol Cell Endocrinol. 2012 Aug 15;359(1-2):2-12. doi: 10.1016/j.mce.2011.06.030. Epub 2011 Jul 8. Mol Cell Endocrinol. 2012. PMID: 21763751 Review.
2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-β1 and activin A signalling.
Ciayadi R, Potdar M, Walton KL, Harrison CA, Kelso GF, Harris SJ, Hearn MT. Ciayadi R, et al. Among authors: walton kl. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5642-5. doi: 10.1016/j.bmcl.2010.12.120. Epub 2010 Dec 30. Bioorg Med Chem Lett. 2011. PMID: 21783359
Activation of latent human GDF9 by a single residue change (Gly 391 Arg) in the mature domain.
Simpson CM, Stanton PG, Walton KL, Chan KL, Ritter LJ, Gilchrist RB, Harrison CA. Simpson CM, et al. Among authors: walton kl. Endocrinology. 2012 Mar;153(3):1301-10. doi: 10.1210/en.2011-1632. Epub 2012 Jan 10. Endocrinology. 2012. PMID: 22234469
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