Walz T - Search Results

1

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.

Arndt JW, Qian F, Smith BA, Quan C, Kilambi KP, Bush MW, Walz T, Pepinsky RB, Bussière T, Hamann S, Cameron TO, Weinreb PH. Arndt JW, et al. Among authors: walz t. Sci Rep. 2018 Apr 23;8(1):6412. doi: 10.1038/s41598-018-24501-0. Sci Rep. 2018. PMID: 29686315 Free PMC article.

2

The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein.

Leksa NC, Chiu PL, Bou-Assaf GM, Quan C, Liu Z, Goodman AB, Chambers MG, Tsutakawa SE, Hammel M, Peters RT, Walz T, Kulman JD. Leksa NC, et al. Among authors: walz t. J Thromb Haemost. 2017 Jun;15(6):1167-1179. doi: 10.1111/jth.13700. Epub 2017 May 3. J Thromb Haemost. 2017. PMID: 28397397 Free PMC article.

3

A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble.

Pepinsky B, Gong BJ, Gao Y, Lehmann A, Ferrant J, Amatucci J, Sun Y, Bush M, Walz T, Pederson N, Cameron T, Wen D. Pepinsky B, et al. Among authors: walz t. Biochemistry. 2017 Aug 22;56(33):4405-4418. doi: 10.1021/acs.biochem.7b00302. Epub 2017 Aug 3. Biochemistry. 2017. PMID: 28715204

4

An ensemble of flexible conformations underlies mechanotransduction by the cadherin-catenin adhesion complex.

Bush M, Alhanshali BM, Qian S, Stanley CB, Heller WT, Matsui T, Weiss TM, Nicholl ID, Walz T, Callaway DJE, Bu Z. Bush M, et al. Among authors: walz t. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21545-21555. doi: 10.1073/pnas.1911489116. Epub 2019 Oct 7. Proc Natl Acad Sci U S A. 2019. PMID: 31591245 Free PMC article.

5

Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding.

Nešić D, Bush M, Spasic A, Li J, Kamata T, Handa M, Filizola M, Walz T, Coller BS. Nešić D, et al. Among authors: walz t. Blood Adv. 2021 Apr 13;5(7):1781-1790. doi: 10.1182/bloodadvances.2020004166. Blood Adv. 2021. PMID: 33760023 Free PMC article.

6

Cryo-EM structure of the human CST-Polα/primase complex in a recruitment state.

Cai SW, Zinder JC, Svetlov V, Bush MW, Nudler E, Walz T, de Lange T. Cai SW, et al. Among authors: walz t. Nat Struct Mol Biol. 2022 Aug;29(8):813-819. doi: 10.1038/s41594-022-00766-y. Epub 2022 May 16. Nat Struct Mol Biol. 2022. PMID: 35578024 Free PMC article.

7

Shelterin is a dimeric complex with extensive structural heterogeneity.

Zinder JC, Olinares PDB, Svetlov V, Bush MW, Nudler E, Chait BT, Walz T, de Lange T. Zinder JC, et al. Among authors: walz t. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2201662119. doi: 10.1073/pnas.2201662119. Epub 2022 Jul 26. Proc Natl Acad Sci U S A. 2022. PMID: 35881804 Free PMC article.

8

Structure-Based Discovery of a Novel Class of Small-Molecule Pure Antagonists of Integrin αVβ3.

Sen S, Spasic A, Sinha A, Wang J, Bush M, Li J, Nešić D, Zhou Y, Angiulli G, Morgan P, Salas-Estrada L, Takagi J, Walz T, Coller BS, Filizola M. Sen S, et al. Among authors: walz t. J Chem Inf Model. 2022 Nov 28;62(22):5607-5621. doi: 10.1021/acs.jcim.2c00999. Epub 2022 Oct 24. J Chem Inf Model. 2022. PMID: 36279366 Free PMC article.

9

Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

Lashuel HA, Hartley DM, Petre BM, Wall JS, Simon MN, Walz T, Lansbury PT Jr. Lashuel HA, et al. Among authors: walz t. J Mol Biol. 2003 Sep 26;332(4):795-808. doi: 10.1016/s0022-2836(03)00927-6. J Mol Biol. 2003. PMID: 12972252

10

Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.

Chen X, Xie C, Nishida N, Li Z, Walz T, Springer TA. Chen X, et al. Among authors: walz t. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14727-32. doi: 10.1073/pnas.1008663107. Epub 2010 Aug 2. Proc Natl Acad Sci U S A. 2010. PMID: 20679211 Free PMC article.

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