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C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists.
Kim MG, Bodor ET, Wang C, Harden TK, Kohn H. Kim MG, et al. Among authors: wang c. J Med Chem. 2003 May 22;46(11):2216-26. doi: 10.1021/jm020572p. J Med Chem. 2003. PMID: 12747793
Expedient syntheses of C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones are reported to begin with 2,5-disubstituted pyridines. ...Acid decarboxylation of the bicyclo[3.3.1]non-3-enes provided the C(8) substi …
Expedient syntheses of C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones are …
Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.
Braymer JJ, Choi JS, DeToma AS, Wang C, Nam K, Kampf JW, Ramamoorthy A, Lim MH. Braymer JJ, et al. Among authors: wang c. Inorg Chem. 2011 Nov 7;50(21):10724-34. doi: 10.1021/ic2012205. Epub 2011 Sep 28. Inorg Chem. 2011. PMID: 21954910 Free PMC article.
Substituent effect on the efficiency of desulfurizative rearrangement of allylic disulfides.
Li Z, Wang C, Fu Y, Guo QX, Liu L. Li Z, et al. Among authors: wang c. J Org Chem. 2008 Aug 15;73(16):6127-36. doi: 10.1021/jo800747g. Epub 2008 Jul 16. J Org Chem. 2008. PMID: 18630882
Only the substitution at R 1 can effectively reduce the free energy barrier of the reaction to less than 20 kcal/mol (a value required to allow the reaction to complete in minutes at 25 degrees C). ...
Only the substitution at R 1 can effectively reduce the free energy barrier of the reaction to less than 20 kcal/mol (a value required to al …
gamma-Lactone Formation in the Addition of Benzenesulfonyl Bromide to Diene and Enyne Esters.
Wang C, Russell GA. Wang C, et al. J Org Chem. 1999 Mar 19;64(6):2066-2069. doi: 10.1021/jo982388a. J Org Chem. 1999. PMID: 11674301
Formation of the C(alpha)-C(beta) bond of gamma-lactones has been achieved in both C(alpha)-->C(beta) and C(beta)-->C(alpha) radical cyclization directions....
Formation of the C(alpha)-C(beta) bond of gamma-lactones has been achieved in both C(alpha)-->C(beta) and …
Theoretical analysis of the detailed mechanism of native chemical ligation reactions.
Wang C, Guo QX, Fu Y. Wang C, et al. Chem Asian J. 2011 May 2;6(5):1241-51. doi: 10.1002/asia.201000760. Epub 2011 Mar 1. Chem Asian J. 2011. PMID: 21365769
The energy barrier of the thiol-thioester exchange step depends on the side-chain steric hindrance of the C-terminal amino acid, whereas that of the acyl-transfer step depends on the side-chain steric hindrance of the N-terminal amino acid....
The energy barrier of the thiol-thioester exchange step depends on the side-chain steric hindrance of the C-terminal amino acid, wher …
Palladium(II)-catalyzed regioselective arylation of naphthylamides with aryl iodides utilizing a quinolinamide bidentate system.
Huang L, Li Q, Wang C, Qi C. Huang L, et al. Among authors: wang c. J Org Chem. 2013 Apr 5;78(7):3030-8. doi: 10.1021/jo400017v. Epub 2013 Feb 20. J Org Chem. 2013. PMID: 23425227
The theoretical calculations suggest that the C-H arylation reaction proceeds through a sequential C-H activation/oxidative addition pathway....
The theoretical calculations suggest that the C-H arylation reaction proceeds through a sequential C-H activation/oxidative ad …
Mechanism of arylboronic acid-catalyzed amidation reaction between carboxylic acids and amines.
Wang C, Yu HZ, Fu Y, Guo QX. Wang C, et al. Org Biomol Chem. 2013 Apr 7;11(13):2140-6. doi: 10.1039/c3ob27367a. Org Biomol Chem. 2013. PMID: 23381564
Subsequently C-N bond formation between the acyloxyboronic acid intermediates and the amine occurs readily to generate the desired amide product. The cleavage of the C-O bond of the tetracoordinate acyl boronate intermediates is the rate-determining step in this pro …
Subsequently C-N bond formation between the acyloxyboronic acid intermediates and the amine occurs readily to generate the desired am …
Hiyama cross-coupling of arenediazonium salts under mild reaction conditions.
Cheng K, Wang C, Ding Y, Song Q, Qi C, Zhang XM. Cheng K, et al. Among authors: wang c. J Org Chem. 2011 Nov 18;76(22):9261-8. doi: 10.1021/jo201437j. Epub 2011 Oct 21. J Org Chem. 2011. PMID: 21995729
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