Wang H - Search Results

1

Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules.

Follis AV, Hammoudeh DI, Wang H, Prochownik EV, Metallo SJ. Follis AV, et al. Among authors: wang h. Chem Biol. 2008 Nov 24;15(11):1149-55. doi: 10.1016/j.chembiol.2008.09.011. Chem Biol. 2008. PMID: 19022175

2

Improved low molecular weight Myc-Max inhibitors.

Wang H, Hammoudeh DI, Follis AV, Reese BE, Lazo JS, Metallo SJ, Prochownik EV. Wang H, et al. Mol Cancer Ther. 2007 Sep;6(9):2399-408. doi: 10.1158/1535-7163.MCT-07-0005. Mol Cancer Ther. 2007. PMID: 17876039

3

Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model.

Mustata G, Follis AV, Hammoudeh DI, Metallo SJ, Wang H, Prochownik EV, Lazo JS, Bahar I. Mustata G, et al. Among authors: wang h. J Med Chem. 2009 Mar 12;52(5):1247-50. doi: 10.1021/jm801278g. J Med Chem. 2009. PMID: 19215087 Free PMC article.

4

Pharmacophore identification of c-Myc inhibitor 10074-G5.

Yap JL, Wang H, Hu A, Chauhan J, Jung KY, Gharavi RB, Prochownik EV, Fletcher S. Yap JL, et al. Among authors: wang h. Bioorg Med Chem Lett. 2013 Jan 1;23(1):370-4. doi: 10.1016/j.bmcl.2012.10.013. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2013. PMID: 23177256 Free PMC article.

5

Disruption of Myc-Max heterodimerization with improved cell-penetrating analogs of the small molecule 10074-G5.

Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu J, Cione E, Kane MA, Fletcher S, Prochownik EV. Wang H, et al. Oncotarget. 2013 Jun;4(6):936-47. doi: 10.18632/oncotarget.1108. Oncotarget. 2013. PMID: 23801058 Free PMC article.

6

Discovery of methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization.

Chauhan J, Wang H, Yap JL, Sabato PE, Hu A, Prochownik EV, Fletcher S. Chauhan J, et al. Among authors: wang h. ChemMedChem. 2014 Oct;9(10):2274-2285. doi: 10.1002/cmdc.201402189. Epub 2014 Jun 27. ChemMedChem. 2014. PMID: 24976143 Free PMC article.

7

Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.

Jung KY, Wang H, Teriete P, Yap JL, Chen L, Lanning ME, Hu A, Lambert LJ, Holien T, Sundan A, Cosford ND, Prochownik EV, Fletcher S. Jung KY, et al. Among authors: wang h. J Med Chem. 2015 Apr 9;58(7):3002-24. doi: 10.1021/jm501440q. Epub 2015 Mar 30. J Med Chem. 2015. PMID: 25734936 Free PMC article.

8

Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion.

Wang H, Sharma L, Lu J, Finch P, Fletcher S, Prochownik EV. Wang H, et al. Oncotarget. 2015 Jun 30;6(18):15857-70. doi: 10.18632/oncotarget.4327. Oncotarget. 2015. PMID: 26036281 Free PMC article.

9

c-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and Function.

Edmunds LR, Sharma L, Wang H, Kang A, d'Souza S, Lu J, McLaughlin M, Dolezal JM, Gao X, Weintraub ST, Ding Y, Zeng X, Yates N, Prochownik EV. Edmunds LR, et al. Among authors: wang h. PLoS One. 2015 Jul 31;10(7):e0134049. doi: 10.1371/journal.pone.0134049. eCollection 2015. PLoS One. 2015. PMID: 26230505 Free PMC article.

10

A quantitative, surface plasmon resonance-based approach to evaluating DNA binding by the c-Myc oncoprotein and its disruption by small molecule inhibitors.

Wang H, Ramakrishnan A, Fletcher S, Prochownik EV. Wang H, et al. J Biol Methods. 2015;2(2):e18. doi: 10.14440/jbm.2015.54. J Biol Methods. 2015. PMID: 26280010 Free PMC article.

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