Wang H - Search Results

1

The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.

Gu C, Nguyen HN, Hofer A, Jessen HJ, Dai X, Wang H, Shears SB. Gu C, et al. Among authors: wang h. J Biol Chem. 2017 Mar 17;292(11):4544-4555. doi: 10.1074/jbc.M116.765743. Epub 2017 Jan 26. J Biol Chem. 2017. PMID: 28126903 Free PMC article.

2

Diphosphoinositol polyphosphates: what are the mechanisms?

Shears SB, Gokhale NA, Wang H, Zaremba A. Shears SB, et al. Among authors: wang h. Adv Enzyme Regul. 2011;51(1):13-25. doi: 10.1016/j.advenzreg.2010.09.008. Epub 2010 Oct 28. Adv Enzyme Regul. 2011. PMID: 21035493 Free PMC article. Review.

3

Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.

Wang H, Falck JR, Hall TM, Shears SB. Wang H, et al. Nat Chem Biol. 2011 Nov 27;8(1):111-6. doi: 10.1038/nchembio.733. Nat Chem Biol. 2011. PMID: 22119861 Free PMC article.

4

Defining signal transduction by inositol phosphates.

Shears SB, Ganapathi SB, Gokhale NA, Schenk TM, Wang H, Weaver JD, Zaremba A, Zhou Y. Shears SB, et al. Among authors: wang h. Subcell Biochem. 2012;59:389-412. doi: 10.1007/978-94-007-3015-1_13. Subcell Biochem. 2012. PMID: 22374098 Free PMC article. Review.

5

Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1.

Zhou Y, Wu S, Wang H, Hayakawa Y, Bird GS, Shears SB. Zhou Y, et al. Among authors: wang h. Biochem J. 2012 Dec 1;448(2):273-83. doi: 10.1042/BJ20120730. Biochem J. 2012. PMID: 22928859 Free PMC article.

6

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase.

Riley AM, Wang H, Weaver JD, Shears SB, Potter BV. Riley AM, et al. Among authors: wang h. Chem Commun (Camb). 2012 Nov 28;48(92):11292-4. doi: 10.1039/c2cc36044f. Chem Commun (Camb). 2012. PMID: 23032903 Free PMC article.

7

Structural insight into inositol pyrophosphate turnover.

Shears SB, Weaver JD, Wang H. Shears SB, et al. Among authors: wang h. Adv Biol Regul. 2013 Jan;53(1):19-27. doi: 10.1016/j.jbior.2012.10.002. Epub 2012 Oct 11. Adv Biol Regul. 2013. PMID: 23107997 Free PMC article. Review.

8

The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment.

Weaver JD, Wang H, Shears SB. Weaver JD, et al. Among authors: wang h. Biosci Rep. 2013 Feb 5;33(2):e00022. doi: 10.1042/BSR20120115. Biosci Rep. 2013. PMID: 23240582 Free PMC article.

9

Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery.

Wang H, Godage HY, Riley AM, Weaver JD, Shears SB, Potter BV. Wang H, et al. Chem Biol. 2014 May 22;21(5):689-99. doi: 10.1016/j.chembiol.2014.03.009. Epub 2014 Apr 24. Chem Biol. 2014. PMID: 24768307 Free PMC article.

10

IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family.

Wang H, DeRose EF, London RE, Shears SB. Wang H, et al. Nat Commun. 2014 Jun 24;5:4178. doi: 10.1038/ncomms5178. Nat Commun. 2014. PMID: 24956979 Free PMC article.

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