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Holins: the protein clocks of bacteriophage infections.
Wang IN, Smith DL, Young R. Wang IN, et al. Annu Rev Microbiol. 2000;54:799-825. doi: 10.1146/annurev.micro.54.1.799. Annu Rev Microbiol. 2000. PMID: 11018145 Review.
Endolysin is the term for muralytic enzymes that degrade the cell wall; endolysins accumulate in the cytosol fully folded during the vegetative cycle. Holins are small membrane proteins that accumulate in the membrane until, at a specific time that is "programmed" i …
Endolysin is the term for muralytic enzymes that degrade the cell wall; endolysins accumulate in the cytosol fully folded during the …
Sizing the holin lesion with an endolysin-beta-galactosidase fusion.
Wang IN, Deaton J, Young R. Wang IN, et al. J Bacteriol. 2003 Feb;185(3):779-87. doi: 10.1128/jb.185.3.779-787.2003. J Bacteriol. 2003. PMID: 12533453 Free PMC article.
Under these conditions, the hybrid R-beta-Gal product, an active tetrameric beta-Gal greater than 480 kDa in mass, was fully functional in lysis mediated by the S holin. ...Similar results were obtained with an early lysis variant of the S holin and also in p …
Under these conditions, the hybrid R-beta-Gal product, an active tetrameric beta-Gal greater than 480 kDa in mass, was fully function …
A signal-arrest-release sequence mediates export and control of the phage P1 endolysin.
Xu M, Struck DK, Deaton J, Wang IN, Young R. Xu M, et al. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6415-20. doi: 10.1073/pnas.0400957101. Epub 2004 Apr 16. Proc Natl Acad Sci U S A. 2004. PMID: 15090650 Free PMC article.
The unusual N-terminal domain, rich in residues that are weakly hydrophobic, thus functions as a signal-arrest-release sequence, which first acts as a normal signal-arrest domain to direct the endolysin to the periplasm in membrane-tethered form and then allows it t …
The unusual N-terminal domain, rich in residues that are weakly hydrophobic, thus functions as a signal-arrest-release sequence, whic …
A(2) expression and assembly regulates lysis in Qβ infections.
Reed CA, Langlais C, Wang IN, Young R. Reed CA, et al. Microbiology (Reading). 2013 Mar;159(Pt 3):507-514. doi: 10.1099/mic.0.064790-0. Epub 2013 Jan 17. Microbiology (Reading). 2013. PMID: 23329676 Free PMC article.
In the Alloleviviridae, represented by the canonical phage Qβ, the maturation protein A(2) also causes lysis. This is achieved by inhibiting the activity of MurA, which catalyses the first committed step of murein biosynthesis. ...Qβ por mutants, isolated as suppressors th
In the Alloleviviridae, represented by the canonical phage Qβ, the maturation protein A(2) also causes lysis. This is achieved by inh
Lysis timing and bacteriophage fitness.
Wang IN. Wang IN. Genetics. 2006 Jan;172(1):17-26. doi: 10.1534/genetics.105.045922. Epub 2005 Oct 11. Genetics. 2006. PMID: 16219778 Free PMC article.
To test the prediction, an array of isogenic lambda-phages that differ only in their lysis times was constructed. For each phage strain, the lysis time, burst size, and fitness (growth rate) were determined. ...
To test the prediction, an array of isogenic lambda-phages that differ only in their lysis times was constructed. For each phage stra …
Breaking free: "protein antibiotics" and phage lysis.
Bernhardt TG, Wang IN, Struck DK, Young R. Bernhardt TG, et al. Res Microbiol. 2002 Oct;153(8):493-501. doi: 10.1016/s0923-2508(02)01330-x. Res Microbiol. 2002. PMID: 12437210 Review.
Factors influencing lysis time stochasticity in bacteriophage λ.
Dennehy JJ, Wang IN. Dennehy JJ, et al. BMC Microbiol. 2011 Aug 2;11:174. doi: 10.1186/1471-2180-11-174. BMC Microbiol. 2011. PMID: 21810267 Free PMC article.
Using the SD as a measure of lysis time stochasticity, we showed that lysogenic cells in controlled environments varied widely in lysis times, and that the level of lysis time stochasticity depended on allelic variation in the holin sequence, late promoter (p …
Using the SD as a measure of lysis time stochasticity, we showed that lysogenic cells in controlled environments varied widely in
Variation of enzyme activities at a branched pathway involved in the utilization of gluconate in Escherichia coli.
Wang IN, Dykhuizen DE. Wang IN, et al. Evolution. 2001 May;55(5):897-908. doi: 10.1554/0014-3820(2001)055[0897:voeaaa]2.0.co;2. Evolution. 2001. PMID: 11430650
Twenty-four strains of Escherichia coli from the ECOR collection were characterized for growth rate in gluconate minimal salts medium and for Vmax and Km of the three enzymes (gluconokinase, 6-phosphogluconate dehydrogenase, and 6-phosphogluconate dehydratase) that form a …
Twenty-four strains of Escherichia coli from the ECOR collection were characterized for growth rate in gluconate minimal salts medium …
A protein antibiotic in the phage Qbeta virion: diversity in lysis targets.
Bernhardt TG, Wang IN, Struck DK, Young R. Bernhardt TG, et al. Science. 2001 Jun 22;292(5525):2326-9. doi: 10.1126/science.1058289. Science. 2001. PMID: 11423662
A(2) blocked synthesis of murein precursors in vivo by inhibiting MurA, the catalyst of the committed step of murein biosynthesis. ...Moreover, purified Qbeta virions inhibited wild-type MurA, but not the mutant MurA, in vitro. Thus, the two small phages characteriz …
A(2) blocked synthesis of murein precursors in vivo by inhibiting MurA, the catalyst of the committed step of murein biosynthesis. .. …
Optimum Threshold Minimizes Noise in Timing of Intracellular Events.
Kannoly S, Gao T, Dey S, Wang IN, Singh A, Dennehy JJ. Kannoly S, et al. Among authors: wang in. iScience. 2020 Jun 26;23(6):101186. doi: 10.1016/j.isci.2020.101186. Epub 2020 May 21. iScience. 2020. PMID: 32504874 Free PMC article.
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