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Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
Wu C, Decker ER, Blok N, Bui H, You TJ, Wang J, Bourgoyne AR, Knowles V, Berens KL, Holland GW, Brock TA, Dixon RA. Wu C, et al. Among authors: wang j. J Med Chem. 2004 Apr 8;47(8):1969-86. doi: 10.1021/jm030528p. J Med Chem. 2004. PMID: 15055997 Clinical Trial.
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