Wang J - Search Results

1

Reversible covalent binding of neratinib to human serum albumin in vitro.

Chandrasekaran A, Shen L, Lockhead S, Oganesian A, Wang J, Scatina J. Chandrasekaran A, et al. Among authors: wang j. Drug Metab Lett. 2010 Dec;4(4):220-7. doi: 10.2174/187231210792928206. Drug Metab Lett. 2010. PMID: 20690900

2

Comparative pharmacokinetics and metabolism studies in lean and diet- induced obese mice: an animal efficacy model for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.

Wang M, Tian X, Leung L, Wang J, Houvig N, Xiang J, Wan ZK, Saiah E, Hahm S, Suri V, Xu X. Wang M, et al. Among authors: wang j. Drug Metab Lett. 2011 Jan;5(1):55-63. doi: 10.2174/187231211794455280. Drug Metab Lett. 2011. PMID: 21198436

3

Characterization of HKI-272 covalent binding to human serum albumin.

Wang J, Li-Chan XX, Atherton J, Deng L, Espina R, Yu L, Horwatt P, Ross S, Lockhead S, Ahmad S, Chandrasekaran A, Oganesian A, Scatina J, Mutlib A, Talaat R. Wang J, et al. Drug Metab Dispos. 2010 Jul;38(7):1083-93. doi: 10.1124/dmd.110.032292. Epub 2010 Apr 16. Drug Metab Dispos. 2010. PMID: 20400660

4

Mechanism study of N-dephenylation mediated through a N-para-hydroxy metabolite.

Wang J, DeMaio W, Chandrasekaran A, Shen L, Bach AC 2nd, Scatina J, Talaat R. Wang J, et al. Curr Drug Discov Technol. 2006 Jun;3(2):101-14. doi: 10.2174/157016306778108901. Curr Drug Discov Technol. 2006. PMID: 16925518

5

Alternate strategies to obtain mass balance without the use of radiolabeled compounds: application of quantitative fluorine (19F) nuclear magnetic resonance (NMR) spectroscopy in metabolism studies.

Mutlib A, Espina R, Atherton J, Wang J, Talaat R, Scatina J, Chandrasekaran A. Mutlib A, et al. Among authors: wang j. Chem Res Toxicol. 2012 Mar 19;25(3):572-83. doi: 10.1021/tx2005629. Epub 2012 Feb 10. Chem Res Toxicol. 2012. PMID: 22292524

6

Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing.

Espina R, Yu L, Wang J, Tong Z, Vashishtha S, Talaat R, Scatina J, Mutlib A. Espina R, et al. Among authors: wang j. Chem Res Toxicol. 2009 Feb;22(2):299-310. doi: 10.1021/tx800251p. Chem Res Toxicol. 2009. PMID: 18980340

7

A novel approach for predicting acyl glucuronide reactivity via Schiff base formation: development of rapidly formed peptide adducts for LC/MS/MS measurements.

Wang J, Davis M, Li F, Azam F, Scatina J, Talaat R. Wang J, et al. Chem Res Toxicol. 2004 Sep;17(9):1206-16. doi: 10.1021/tx049900+. Chem Res Toxicol. 2004. PMID: 15377154

8

Liquid chromatography/mass spectrometry determination of endogenous plasma acetyl and palmitoyl carnitines as potential biomarkers of beta-oxidation in mice.

Liu Z, Mutlib AE, Wang J, Talaat RE. Liu Z, et al. Among authors: wang j. Rapid Commun Mass Spectrom. 2008 Nov;22(21):3434-42. doi: 10.1002/rcm.3755. Rapid Commun Mass Spectrom. 2008. PMID: 18837479

9

Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates.

Ayral-Kaloustian S, Gu J, Lucas J, Cinque M, Gaydos C, Zask A, Chaudhary I, Wang J, Di L, Young M, Ruppen M, Mansour TS, Gibbons JJ, Yu K. Ayral-Kaloustian S, et al. Among authors: wang j. J Med Chem. 2010 Jan 14;53(1):452-9. doi: 10.1021/jm901427g. J Med Chem. 2010. PMID: 19928864

10

Optimization of 5-vinylaryl-3-pyridinecarbonitriles as PKCtheta inhibitors.

Boschelli DH, Subrath J, Niu C, Wu B, Wang Y, Lee J, Brennan A, Ho M, Deng B, Yang X, Xu X, Leung L, Wang J, Atherton J, Chaudhary D. Boschelli DH, et al. Among authors: wang j, wang y. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1965-8. doi: 10.1016/j.bmcl.2010.01.119. Epub 2010 Jan 28. Bioorg Med Chem Lett. 2010. PMID: 20153643

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