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Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes.
Wang T, Sharma AK, Wu C, Maushart CI, Ghosh A, Yang W, Stefanicka P, Kovanicova Z, Ukropec J, Zhang J, Arnold M, Klug M, De Bock K, Schneider U, Popescu C, Zheng B, Ding L, Long F, Dewal RS, Moser C, Sun W, Dong H, Takes M, Suelberg D, Mameghani A, Nocito A, Zech CJ, Chirindel A, Wild D, Burger IA, Schön MR, Dietrich A, Gao M, Heine M, Sun Y, Vargas-Castillo A, Søberg S, Scheele C, Balaz M, Blüher M, Betz MJ, Spiegelman BM, Wolfrum C. Wang T, et al. Cell Metab. 2024 Sep 3;36(9):2130-2145.e7. doi: 10.1016/j.cmet.2024.07.005. Epub 2024 Jul 30. Cell Metab. 2024. PMID: 39084216 Free article.
Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization.
Zhang J, Muri J, Fitzgerald G, Gorski T, Gianni-Barrera R, Masschelein E, D'Hulst G, Gilardoni P, Turiel G, Fan Z, Wang T, Planque M, Carmeliet P, Pellerin L, Wolfrum C, Fendt SM, Banfi A, Stockmann C, Soro-Arnáiz I, Kopf M, De Bock K. Zhang J, et al. Among authors: wang t. Cell Metab. 2020 Jun 2;31(6):1136-1153.e7. doi: 10.1016/j.cmet.2020.05.004. Cell Metab. 2020. PMID: 32492393 Free PMC article.
Novel insights into adipose tissue heterogeneity.
Wang T, Sharma AK, Wolfrum C. Wang T, et al. Rev Endocr Metab Disord. 2022 Feb;23(1):5-12. doi: 10.1007/s11154-021-09703-8. Epub 2021 Dec 21. Rev Endocr Metab Disord. 2022. PMID: 34935088 Free PMC article. Review.
An integrated single cell and spatial transcriptomic map of human white adipose tissue.
Massier L, Jalkanen J, Elmastas M, Zhong J, Wang T, Nono Nankam PA, Frendo-Cumbo S, Bäckdahl J, Subramanian N, Sekine T, Kerr AG, Tseng BTP, Laurencikiene J, Buggert M, Lourda M, Kublickiene K, Bhalla N, Andersson A, Valsesia A, Astrup A, Blaak EE, Ståhl PL, Viguerie N, Langin D, Wolfrum C, Blüher M, Rydén M, Mejhert N. Massier L, et al. Among authors: wang t. Nat Commun. 2023 Mar 15;14(1):1438. doi: 10.1038/s41467-023-36983-2. Nat Commun. 2023. PMID: 36922516 Free PMC article.
Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape.
Reinisch I, Michenthaler H, Sulaj A, Moyschewitz E, Krstic J, Galhuber M, Xu R, Riahi Z, Wang T, Vujic N, Amor M, Zenezini Chiozzi R, Wabitsch M, Kolb D, Georgiadi A, Glawitsch L, Heitzer E, Schulz TJ, Schupp M, Sun W, Dong H, Ghosh A, Hoffmann A, Kratky D, Hinte LC, von Meyenn F, Heck AJR, Blüher M, Herzig S, Wolfrum C, Prokesch A. Reinisch I, et al. Among authors: wang t. Nat Commun. 2024 Feb 15;15(1):1391. doi: 10.1038/s41467-024-45724-y. Nat Commun. 2024. PMID: 38360943 Free PMC article.
Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL.
Ding L, Huwyler F, Long F, Yang W, Binz J, Wernlé K, Pfister M, Klug M, Balaz M, Ukropcova B, Ukropec J, Wu C, Wang T, Gao M, Clavien PA, Dutkowski P, Tibbitt MW, Wolfrum C. Ding L, et al. Among authors: wang t. Nat Cell Biol. 2024 Apr;26(4):552-566. doi: 10.1038/s41556-024-01386-y. Epub 2024 Apr 1. Nat Cell Biol. 2024. PMID: 38561547 Free PMC article.
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.
Vargas-Castillo A, Sun Y, Smythers AL, Grauvogel L, Dumesic PA, Emont MP, Tsai LT, Rosen ED, Zammit NW, Shaffer SM, Ordonez M, Chouchani ET, Gygi SP, Wang T, Sharma AK, Balaz M, Wolfrum C, Spiegelman BM. Vargas-Castillo A, et al. Among authors: wang t. Cell Metab. 2024 Sep 3;36(9):2146-2155.e5. doi: 10.1016/j.cmet.2024.07.002. Epub 2024 Jul 30. Cell Metab. 2024. PMID: 39084217 Free PMC article.
Endothelial metabolic control of insulin sensitivity through resident macrophages.
Zhang J, Sjøberg KA, Gong S, Wang T, Li F, Kuo A, Durot S, Majcher A, Ardicoglu R, Desgeorges T, Mann CG, Soro Arnáiz I, Fitzgerald G, Gilardoni P, Abel ED, Kon S, Olivares-Villagómez D, Zamboni N, Wolfrum C, Hornemann T, Morscher R, Tisch N, Ghesquière B, Kopf M, Richter EA, De Bock K. Zhang J, et al. Among authors: wang t. Cell Metab. 2024 Nov 5;36(11):2383-2401.e9. doi: 10.1016/j.cmet.2024.08.008. Epub 2024 Sep 12. Cell Metab. 2024. PMID: 39270655 Free article.
Glucagon controls obesity-specific energy expenditure via persistent cAMP/PKA signaling.
Long F, Challa TD, Ding L, Sharma AK, Wu C, Ghosh A, Noé F, Horvath C, Liebisch G, Höring M, Wang T, Klug M, Zimmermann T, Pereira MMA, Rist W, Strobel B, Pekcec A, Neubauer H, Wolfrum C. Long F, et al. Among authors: wang t. J Hepatol. 2025 Dec;83(6):1379-1391. doi: 10.1016/j.jhep.2025.06.011. Epub 2025 Jun 21. J Hepatol. 2025. PMID: 40550339 Free article.
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