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Regulation of PKC-θ function by phosphorylation in T cell receptor signaling.
Wang X, Chuang HC, Li JP, Tan TH. Wang X, et al. Front Immunol. 2012 Jul 11;3:197. doi: 10.3389/fimmu.2012.00197. eCollection 2012. Front Immunol. 2012. PMID: 22798961 Free PMC article.
Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells.
Yamada T, Gierach K, Lee PH, Wang X, Lacorazza HD. Yamada T, et al. Among authors: wang x. J Immunol. 2010 Oct 1;185(7):3824-8. doi: 10.4049/jimmunol.1000718. Epub 2010 Aug 27. J Immunol. 2010. PMID: 20802152 Free PMC article.
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells.
Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH. Chuang HC, et al. Among authors: wang x. Nat Immunol. 2011 Oct 9;12(11):1113-8. doi: 10.1038/ni.2121. Nat Immunol. 2011. PMID: 21983831
Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK).
Wang X, Li JP, Kuo HK, Chiu LL, Dement GA, Lan JL, Chen DY, Yang CY, Hu H, Tan TH. Wang X, et al. J Biol Chem. 2012 Mar 30;287(14):11037-48. doi: 10.1074/jbc.M111.310946. Epub 2012 Feb 10. J Biol Chem. 2012. PMID: 22334673 Free PMC article.
Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein.
Wang X, Li JP, Chiu LL, Lan JL, Chen DY, Boomer J, Tan TH. Wang X, et al. J Biol Chem. 2012 Oct 5;287(41):34091-100. doi: 10.1074/jbc.M112.371062. Epub 2012 Aug 17. J Biol Chem. 2012. PMID: 22902619 Free PMC article.
The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck.
Li JP, Yang CY, Chuang HC, Lan JL, Chen DY, Chen YM, Wang X, Chen AJ, Belmont JW, Tan TH. Li JP, et al. Among authors: wang x. Nat Commun. 2014 Apr 9;5:3618. doi: 10.1038/ncomms4618. Nat Commun. 2014. PMID: 24714587
HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance.
Chuang HC, Sheu WH, Lin YT, Tsai CY, Yang CY, Cheng YJ, Huang PY, Li JP, Chiu LL, Wang X, Xie M, Schneider MD, Tan TH. Chuang HC, et al. Among authors: wang x. Nat Commun. 2014 Aug 6;5:4602. doi: 10.1038/ncomms5602. Nat Commun. 2014. PMID: 25098764 Free PMC article.
MAP4K Family Kinases in Immunity and Inflammation.
Chuang HC, Wang X, Tan TH. Chuang HC, et al. Among authors: wang x. Adv Immunol. 2016;129:277-314. doi: 10.1016/bs.ai.2015.09.006. Epub 2015 Oct 26. Adv Immunol. 2016. PMID: 26791862 Review.
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.
Deng R, Zuo C, Li Y, Xue B, Xun Z, Guo Y, Wang X, Xu Y, Tian R, Chen S, Liu Q, Chen J, Wang J, Huang X, Li H, Guo M, Wang X, Yang M, Wu Z, Wang J, Ma J, Hu J, Li G, Tang S, Tu Z, Ji H, Zhu H. Deng R, et al. Among authors: wang x, wang j, wang x, wang j. Cell Mol Immunol. 2020 Sep 22. doi: 10.1038/s41423-020-00549-9. Online ahead of print. Cell Mol Immunol. 2020. PMID: 32963356
Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis.
Chen Y, Wang X, Di L, Fu G, Chen Y, Bai L, Liu J, Feng X, McDonald JM, Michalek S, He Y, Yu M, Fu YX, Wen R, Wu H, Wang D. Chen Y, et al. Among authors: wang x, wang d. J Biol Chem. 2008 Oct 24;283(43):29593-601. doi: 10.1074/jbc.M802493200. Epub 2008 Aug 26. J Biol Chem. 2008. PMID: 18728019 Free PMC article.
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