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Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols.
Dinkova-Kostova AT, Wang XJ. Dinkova-Kostova AT, et al. Among authors: wang xj. Chem Biol Interact. 2011 Jun 30;192(1-2):101-6. doi: 10.1016/j.cbi.2010.09.010. Epub 2010 Sep 21. Chem Biol Interact. 2011. PMID: 20846517
Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs.
Wang XJ, Li Y, Luo L, Wang H, Chi Z, Xin A, Li X, Wu J, Tang X. Wang XJ, et al. Among authors: wang h. Free Radic Biol Med. 2014 May;70:68-77. doi: 10.1016/j.freeradbiomed.2014.02.010. Epub 2014 Feb 18. Free Radic Biol Med. 2014. PMID: 24556415
An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.
Dinkova-Kostova AT, Talalay P, Sharkey J, Zhang Y, Holtzclaw WD, Wang XJ, David E, Schiavoni KH, Finlayson S, Mierke DF, Honda T. Dinkova-Kostova AT, et al. Among authors: wang xj. J Biol Chem. 2010 Oct 29;285(44):33747-55. doi: 10.1074/jbc.M110.163485. Epub 2010 Aug 26. J Biol Chem. 2010. PMID: 20801881 Free PMC article.
Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.
Wang XJ, Hayes JD, Higgins LG, Wolf CR, Dinkova-Kostova AT. Wang XJ, et al. Chem Biol. 2010 Jan 29;17(1):75-85. doi: 10.1016/j.chembiol.2009.12.013. Chem Biol. 2010. PMID: 20142043
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
Wang XJ, Hayes JD, Henderson CJ, Wolf CR. Wang XJ, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19589-94. doi: 10.1073/pnas.0709483104. Epub 2007 Nov 28. Proc Natl Acad Sci U S A. 2007. PMID: 18048326 Free PMC article.
Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.
Wang XJ, Hayes JD, Wolf CR. Wang XJ, et al. Cancer Res. 2006 Nov 15;66(22):10983-94. doi: 10.1158/0008-5472.CAN-06-2298. Cancer Res. 2006. PMID: 17108137
RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2.
Wang H, Liu K, Geng M, Gao P, Wu X, Hai Y, Li Y, Li Y, Luo L, Hayes JD, Wang XJ, Tang X. Wang H, et al. Among authors: wang xj. Cancer Res. 2013 May 15;73(10):3097-108. doi: 10.1158/0008-5472.CAN-12-3386. Epub 2013 Apr 23. Cancer Res. 2013. PMID: 23612120
[Down-regulation of Nrf2-ARE signaling pathway].
Wang XJ, Wu JG, Tang XW. Wang XJ, et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Jan;39(1):1-5. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010. PMID: 20175228 Chinese. No abstract available.
[Nrf2 down-regulated cell line H460-N5 with Keap1 over-expression increased sensitivity to anti-cancer drugs].
Qu LY, Gao P, Wang HY, Wang XJ, Tang XW. Qu LY, et al. Among authors: wang xj, wang hy. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Jan;39(1):6-10. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010. PMID: 20175229 Chinese.
Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer.
Namani A, Li Y, Wang XJ, Tang X. Namani A, et al. Among authors: wang xj. Biochim Biophys Acta. 2014 Sep;1843(9):1875-85. doi: 10.1016/j.bbamcr.2014.05.003. Epub 2014 May 20. Biochim Biophys Acta. 2014. PMID: 24851839 Review.
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