Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth.
Wang Y, Zhang X, Tian J, Shan J, Hu Y, Zhai Y, Guo J.
Wang Y, et al.
FASEB J. 2019 May;33(5):6311-6326. doi: 10.1096/fj.201801949RR. Epub 2019 Feb 15.
FASEB J. 2019.
PMID: 30768370
Our study suggests interactions between the intracellular inward tension in talin and the outward osmotic pressure as the effective channel for promoting neurite outgrowth, which can be up-regulated by integrin activation and down-regulated by DOK1.-Wang, Y., Zhang, …
Our study suggests interactions between the intracellular inward tension in talin and the outward osmotic pressure as the effective channel …