Wanhainen KM - Search Results

1

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors.

Long AH, Haso WM, Shern JF, Wanhainen KM, Murgai M, Ingaramo M, Smith JP, Walker AJ, Kohler ME, Venkateshwara VR, Kaplan RN, Patterson GH, Fry TJ, Orentas RJ, Mackall CL. Long AH, et al. Among authors: wanhainen km. Nat Med. 2015 Jun;21(6):581-90. doi: 10.1038/nm.3838. Epub 2015 May 4. Nat Med. 2015. PMID: 25939063 Free PMC article.

2

Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase.

Walker AJ, Majzner RG, Zhang L, Wanhainen K, Long AH, Nguyen SM, Lopomo P, Vigny M, Fry TJ, Orentas RJ, Mackall CL. Walker AJ, et al. Mol Ther. 2017 Sep 6;25(9):2189-2201. doi: 10.1016/j.ymthe.2017.06.008. Epub 2017 Jul 1. Mol Ther. 2017. PMID: 28676342 Free PMC article.

3

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance.

Yang Y, Kohler ME, Chien CD, Sauter CT, Jacoby E, Yan C, Hu Y, Wanhainen K, Qin H, Fry TJ. Yang Y, et al. Sci Transl Med. 2017 Nov 22;9(417):eaag1209. doi: 10.1126/scitranslmed.aag1209. Sci Transl Med. 2017. PMID: 29167392 Free PMC article.

4

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.

Wanhainen KM, Peng C, Zhou MH, Macedo BG, O'Flanagan S, Yang T, Kelekar A, Burbach BJ, Borges da Silva H, Jameson SC. Wanhainen KM, et al. Cancer Immunol Res. 2022 Jul 1;10(7):871-884. doi: 10.1158/2326-6066.CIR-21-0691. Cancer Immunol Res. 2022. PMID: 35588154 Free PMC article.

5

Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8⁺ T cell subsets.

Jarjour NN, Wanhainen KM, Peng C, Gavil NV, Maurice NJ, Borges da Silva H, Martinez RJ, Dalzell TS, Huggins MA, Masopust D, Hamilton SE, Jameson SC. Jarjour NN, et al. Among authors: wanhainen km. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2209021119. doi: 10.1073/pnas.2209021119. Epub 2022 Oct 19. Proc Natl Acad Sci U S A. 2022. PMID: 36260745 Free PMC article.

6

Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8⁺ tissue-resident memory T cells.

Peng C, Huggins MA, Wanhainen KM, Knutson TP, Lu H, Georgiev H, Mittelsteadt KL, Jarjour NN, Wang H, Hogquist KA, Campbell DJ, Borges da Silva H, Jameson SC. Peng C, et al. Among authors: wanhainen km. Immunity. 2022 Jan 11;55(1):98-114.e5. doi: 10.1016/j.immuni.2021.11.017. Epub 2021 Dec 20. Immunity. 2022. PMID: 34932944 Free PMC article.

7

Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8⁺ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β.

Borges da Silva H, Peng C, Wang H, Wanhainen KM, Ma C, Lopez S, Khoruts A, Zhang N, Jameson SC. Borges da Silva H, et al. Among authors: wanhainen km. Immunity. 2020 Jul 14;53(1):158-171.e6. doi: 10.1016/j.immuni.2020.06.010. Epub 2020 Jul 7. Immunity. 2020. PMID: 32640257 Free PMC article.

8

The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8⁺ T Cells.

Vardam-Kaur T, van Dijk S, Peng C, Wanhainen KM, Jameson SC, Borges da Silva H. Vardam-Kaur T, et al. Among authors: wanhainen km. J Immunol. 2022 Apr 1;208(7):1686-1699. doi: 10.4049/jimmunol.2100555. Epub 2022 Mar 9. J Immunol. 2022. PMID: 35264459 Free PMC article.

9

Self-Regulation of Memory CD8 T Cell Metabolism through Extracellular ATP Signaling.

Wanhainen KM, Jameson SC, da Silva HB. Wanhainen KM, et al. Immunometabolism. 2019;1(1):e190009. doi: 10.20900/immunometab20190009. Epub 2019 Jul 23. Immunometabolism. 2019. PMID: 31428464 Free PMC article.

10

Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases.

Kober DL, Wanhainen KM, Johnson BM, Randolph DT, Holtzman MJ, Brett TJ. Kober DL, et al. Among authors: wanhainen km. Protein Expr Purif. 2014 Apr;96:32-8. doi: 10.1016/j.pep.2014.01.015. Epub 2014 Feb 7. Protein Expr Purif. 2014. PMID: 24508568 Free PMC article.

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