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148 results
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Therapy effects of green tea in a patient with systemic light-chain amyloidosis.
Mereles D, Wanker EE, Katus HA. Mereles D, et al. Among authors: wanker ee. Clin Res Cardiol. 2008 May;97(5):341-4. doi: 10.1007/s00392-008-0649-6. Epub 2008 Mar 3. Clin Res Cardiol. 2008. PMID: 18317666 No abstract available.
Green tea halts progression of cardiac transthyretin amyloidosis: an observational report.
Kristen AV, Lehrke S, Buss S, Mereles D, Steen H, Ehlermann P, Hardt S, Giannitsis E, Schreiner R, Haberkorn U, Schnabel PA, Linke RP, Röcken C, Wanker EE, Dengler TJ, Altland K, Katus HA. Kristen AV, et al. Among authors: wanker ee. Clin Res Cardiol. 2012 Oct;101(10):805-13. doi: 10.1007/s00392-012-0463-z. Epub 2012 May 15. Clin Res Cardiol. 2012. PMID: 22584381 Free PMC article. Clinical Trial.
Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate.
Andrich K, Hegenbart U, Kimmich C, Kedia N, Bergen HR 3rd, Schönland S, Wanker E, Bieschke J. Andrich K, et al. J Biol Chem. 2017 Feb 10;292(6):2328-2344. doi: 10.1074/jbc.M116.750323. Epub 2016 Dec 28. J Biol Chem. 2017. PMID: 28031465 Free PMC article.
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.
Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE. Ehrnhoefer DE, et al. Among authors: wanker ee. Hum Mol Genet. 2006 Sep 15;15(18):2743-51. doi: 10.1093/hmg/ddl210. Epub 2006 Aug 7. Hum Mol Genet. 2006. PMID: 16893904
The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.
Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R, Krauß S. Schweiger S, et al. J Biol Chem. 2014 Nov 14;289(46):31805-17. doi: 10.1074/jbc.M113.541219. Epub 2014 Oct 2. J Biol Chem. 2014. PMID: 25278022 Free PMC article.
The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.
Wobst HJ, Sharma A, Diamond MI, Wanker EE, Bieschke J. Wobst HJ, et al. Among authors: wanker ee. FEBS Lett. 2015 Jan 2;589(1):77-83. doi: 10.1016/j.febslet.2014.11.026. Epub 2014 Nov 29. FEBS Lett. 2015. PMID: 25436420 Free PMC article.
EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.
Bieschke J, Russ J, Friedrich RP, Ehrnhoefer DE, Wobst H, Neugebauer K, Wanker EE. Bieschke J, et al. Among authors: wanker ee. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7710-5. doi: 10.1073/pnas.0910723107. Epub 2010 Apr 12. Proc Natl Acad Sci U S A. 2010. PMID: 20385841 Free PMC article.
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.
Ehrnhoefer DE, Bieschke J, Boeddrich A, Herbst M, Masino L, Lurz R, Engemann S, Pastore A, Wanker EE. Ehrnhoefer DE, et al. Among authors: wanker ee. Nat Struct Mol Biol. 2008 Jun;15(6):558-66. doi: 10.1038/nsmb.1437. Epub 2008 May 30. Nat Struct Mol Biol. 2008. PMID: 18511942
Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE. Busch A, et al. Among authors: wanker ee. J Biol Chem. 2003 Oct 17;278(42):41452-61. doi: 10.1074/jbc.M303354200. Epub 2003 Jul 29. J Biol Chem. 2003. PMID: 12888569
Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.
Franko A, Rodriguez Camargo DC, Böddrich A, Garg D, Rodriguez Camargo A, Rathkolb B, Janik D, Aichler M, Feuchtinger A, Neff F, Fuchs H, Wanker EE, Reif B, Häring HU, Peter A, Hrabě de Angelis M. Franko A, et al. Among authors: wanker ee. Sci Rep. 2018 Jan 18;8(1):1116. doi: 10.1038/s41598-017-18807-8. Sci Rep. 2018. PMID: 29348618 Free PMC article.
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