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Combining lipoic acid to methylene blue reduces the Warburg effect in CHO cells: From TCA cycle activation to enhancing monoclonal antibody production.
Montégut L, Martínez-Basilio PC, da Veiga Moreira J, Schwartz L, Jolicoeur M. Montégut L, et al. PLoS One. 2020 Apr 16;15(4):e0231770. doi: 10.1371/journal.pone.0231770. eCollection 2020. PLoS One. 2020. PMID: 32298377 Free PMC article.
The Warburg effect, a hallmark of cancer, has recently been identified as a metabolic limitation of Chinese Hamster Ovary (CHO) cells, the primary platform for the production of monoclonal antibodies (mAb). ...The electron shuttle function of a second drug, methy …
The Warburg effect, a hallmark of cancer, has recently been identified as a metabolic limitation of Chinese Hamster Ovary (CHO …
Singlet Oxygen-Induced Mitochondrial Reset in Cancer: A Novel Approach for Ovarian Cancer Therapy.
da Veiga Moreira J, Schwartz L, Jolicoeur M. da Veiga Moreira J, et al. Metabolites. 2024 Nov 21;14(12):648. doi: 10.3390/metabo14120648. Metabolites. 2024. PMID: 39728429 Free PMC article.
Background/Objectives: This study explores the generation of singlet oxygen (SO) through methylene blue (MB) activation as a metabolic intervention for ovarian cancer. We aimed to examine the role of SO in modulating mitochondrial function, cellular metabolism, and …
Background/Objectives: This study explores the generation of singlet oxygen (SO) through methylene blue (MB) activation as a m …
Cancer and Alzheimer's disease: intracellular pH scales the metabolic disorders.
Schwartz L, Peres S, Jolicoeur M, da Veiga Moreira J. Schwartz L, et al. Biogerontology. 2020 Dec;21(6):683-694. doi: 10.1007/s10522-020-09888-6. Epub 2020 Jul 2. Biogerontology. 2020. PMID: 32617766 Review.
We assume that inflammation is directly responsible of the Warburg effect in cancer cells, with a decreased oxidative phosphorylation and a compensatory highthroughput glycolysis (HTG). ...The link between AD and cancer is reinforced by the fact that t …
We assume that inflammation is directly responsible of the Warburg effect in cancer cells, with a decreased oxidative …
Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots.
Yang SH, Li W, Sumien N, Forster M, Simpkins JW, Liu R. Yang SH, et al. Prog Neurobiol. 2017 Oct;157:273-291. doi: 10.1016/j.pneurobio.2015.10.005. Epub 2015 Nov 18. Prog Neurobiol. 2017. PMID: 26603930 Free PMC article. Review.
In addition, methylene blue provides protective effect in neuron and astrocyte against various insults in vitro and in rodent models of Alzheimer's, Parkinson's, and Huntington's disease. In glioblastoma cells, methylene blue reverses Warburg …
In addition, methylene blue provides protective effect in neuron and astrocyte against various insults in vitro and in …
Study of possibility of cell recognition in brain tumors.
Maklygina YS, Skobeltsin AS, Savelieva TA, Pavlova GV, Chekhonin IV, Gurina OI, Chernysheva AA, Cherepanov SA, Loschenov VB. Maklygina YS, et al. Front Optoelectron. 2020 Dec;13(4):371-380. doi: 10.1007/s12200-020-1095-y. Epub 2020 Dec 23. Front Optoelectron. 2020. PMID: 36641567 Free PMC article.
Cancers, including glioblastoma, have a high glucose uptake and rely on aerobic glycolysis for energy metabolism. The alternation of high-efficiency oxidative phosphorylation to a low-efficiency aerobic glycolysis pathway (Warburg effect) provides macr …
Cancers, including glioblastoma, have a high glucose uptake and rely on aerobic glycolysis for energy metabolism. The alternation of high-ef …