Retrograde BMP signaling controls synaptic growth at the NMJ by regulating trio expression in motor neurons

Neuron. 2010 May 27;66(4):536-49. doi: 10.1016/j.neuron.2010.04.011.

Abstract

Retrograde signaling is essential for coordinating the growth of synaptic structures; however, it is not clear how it can lead to modulation of cytoskeletal dynamics and structural changes at presynaptic terminals. We show that loss of retrograde bone morphogenic protein (BMP) signaling at the Drosophila larval neuromuscular junction (NMJ) leads to a significant reduction in levels of Rac GEF Trio and a diminution of transcription at the trio locus. We further find that Trio is required in motor neurons for normal structural growth. Finally, we show that transgenic expression of Trio in motor neurons can partially restore NMJ defects in larvae mutant for BMP signaling. Based on our findings, we propose a model in which a retrograde BMP signal from the muscle modulates GTPase activity through transcriptional regulation of Rac GEF trio, thereby regulating the homeostasis of synaptic growth at the NMJ.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / physiology*
  • Cell Line
  • Drosophila
  • Drosophila Proteins / biosynthesis*
  • Gene Expression Regulation, Developmental
  • Guanine Nucleotide Exchange Factors / biosynthesis*
  • Humans
  • Motor Neurons / physiology*
  • Neuromuscular Junction / physiology*
  • Phosphoproteins / biosynthesis*
  • Protein Serine-Threonine Kinases / biosynthesis*
  • Signal Transduction / physiology
  • Synapses / physiology*
  • Synapses / ultrastructure

Substances

  • Bone Morphogenetic Proteins
  • Drosophila Proteins
  • Guanine Nucleotide Exchange Factors
  • Phosphoproteins
  • Protein Serine-Threonine Kinases
  • trio protein, Drosophila