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Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity.
Altmann KH, Wartmann M, O'Reilly T. Altmann KH, et al. Among authors: wartmann m. Biochim Biophys Acta. 2000 May 17;1470(3):M79-91. doi: 10.1016/s0304-419x(00)00009-3. Biochim Biophys Acta. 2000. PMID: 10799747 Review. No abstract available.
Synthesis and biological evaluation of highly potent analogues of epothilones B and D.
Altmann KH, Bold G, Caravatti G, Flörsheimer A, Guagnano V, Wartmann M. Altmann KH, et al. Among authors: wartmann m. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2765-8. doi: 10.1016/s0960-894x(00)00555-2. Bioorg Med Chem Lett. 2000. PMID: 11133086
Chemical synthesis and biological properties of pyridine epothilones.
Nicolaou KC, Scarpelli R, Bollbuck B, Werschkun B, Pereira MM, Wartmann M, Altmann KH, Zaharevitz D, Gussio R, Giannakakou P. Nicolaou KC, et al. Among authors: wartmann m. Chem Biol. 2000 Aug;7(8):593-9. doi: 10.1016/s1074-5521(00)00006-5. Chem Biol. 2000. PMID: 11048950
The biology and medicinal chemistry of epothilones.
Wartmann M, Altmann KH. Wartmann M, et al. Curr Med Chem Anticancer Agents. 2002 Jan;2(1):123-48. doi: 10.2174/1568011023354489. Curr Med Chem Anticancer Agents. 2002. PMID: 12678754 Review.
Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma.
O'Reilly T, Wartmann M, Maira SM, Hattenberger M, Vaxelaire J, Muller M, Ferretti S, Buchdunger E, Altmann KH, McSheehy PMJ. O'Reilly T, et al. Among authors: wartmann m. Cancer Chemother Pharmacol. 2005 Apr;55(4):307-317. doi: 10.1007/s00280-004-0913-z. Epub 2004 Oct 26. Cancer Chemother Pharmacol. 2005. PMID: 15723258
Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom?
Bold G, Wojeik S, Caravatti G, Lindauer R, Stierlin C, Gertsch J, Wartmann M, Altmann KH. Bold G, et al. Among authors: wartmann m. ChemMedChem. 2006 Jan;1(1):37-40. doi: 10.1002/cmdc.200500051. ChemMedChem. 2006. PMID: 16892331 No abstract available.
Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity.
Feyen F, Gertsch J, Wartmann M, Altmann KH. Feyen F, et al. Among authors: wartmann m. Angew Chem Int Ed Engl. 2006 Sep 4;45(35):5880-5. doi: 10.1002/anie.200601359. Angew Chem Int Ed Engl. 2006. PMID: 16871640 No abstract available.
Extended kinase profile and properties of the protein kinase inhibitor nilotinib.
Manley PW, Drueckes P, Fendrich G, Furet P, Liebetanz J, Martiny-Baron G, Mestan J, Trappe J, Wartmann M, Fabbro D. Manley PW, et al. Among authors: wartmann m. Biochim Biophys Acta. 2010 Mar;1804(3):445-53. doi: 10.1016/j.bbapap.2009.11.008. Epub 2009 Nov 14. Biochim Biophys Acta. 2010. PMID: 19922818
Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805.
Baffert F, Régnier CH, De Pover A, Pissot-Soldermann C, Tavares GA, Blasco F, Brueggen J, Chène P, Drueckes P, Erdmann D, Furet P, Gerspacher M, Lang M, Ledieu D, Nolan L, Ruetz S, Trappe J, Vangrevelinghe E, Wartmann M, Wyder L, Hofmann F, Radimerski T. Baffert F, et al. Among authors: wartmann m. Mol Cancer Ther. 2010 Jul;9(7):1945-55. doi: 10.1158/1535-7163.MCT-10-0053. Epub 2010 Jun 29. Mol Cancer Ther. 2010. PMID: 20587663
Natural products as leads for anticancer drug discovery: discovery of new chemotypes of microtubule stabilizers through reengineering of the epothilone scaffold.
Altmann KH, Cachoux F, Feyen F, Gertsch J, Kuzniewski CN, Wartmann M. Altmann KH, et al. Among authors: wartmann m. Chimia (Aarau). 2010;64(1-2):8-13. doi: 10.2533/chimia.2010.8. Chimia (Aarau). 2010. PMID: 21137676
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