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Page 1
A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand.
Mikhailova AG, Mikhailova AA, Ushakova K, Tretiakov EO, Iliushchenko D, Shamansky V, Lobanova V, Kozenkov I, Efimenko B, Yurchenko AA, Kozenkova E, Zdobnov EM, Makeev V, Yurov V, Tanaka M, Gostimskaya I, Fleischmann Z, Annis S, Franco M, Wasko K, Denisov S, Kunz WS, Knorre D, Mazunin I, Nikolaev S, Fellay J, Reymond A, Khrapko K, Gunbin K, Popadin K. Mikhailova AG, et al. Among authors: wasko k. Nucleic Acids Res. 2022 Oct 14;50(18):10264-10277. doi: 10.1093/nar/gkac779. Nucleic Acids Res. 2022. PMID: 36130228 Free PMC article.
Methylation-Sensitive Restriction Enzyme Quantitative Polymerase Chain Reaction Enables Rapid, Accurate, and Precise Detection of Methylation Status of the Regulatory T Cell (Treg)-Specific Demethylation Region in Primary Human Tregs.
Perry N, Wasko K, Cheng J, Tabbaa D, Marco E, Giannoukos G, Albright CF, Borges CM. Perry N, et al. Among authors: wasko k. J Immunol. 2021 Jan 15;206(2):446-451. doi: 10.4049/jimmunol.1901275. Epub 2020 Dec 4. J Immunol. 2021. PMID: 33277386
AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines.
Zhang L, Zuris JA, Viswanathan R, Edelstein JN, Turk R, Thommandru B, Rube HT, Glenn SE, Collingwood MA, Bode NM, Beaudoin SF, Lele S, Scott SN, Wasko KM, Sexton S, Borges CM, Schubert MS, Kurgan GL, McNeill MS, Fernandez CA, Myer VE, Morgan RA, Behlke MA, Vakulskas CA. Zhang L, et al. Nat Commun. 2021 Jun 23;12(1):3908. doi: 10.1038/s41467-021-24017-8. Nat Commun. 2021. PMID: 34162850 Free PMC article.
Author Correction: AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines.
Zhang L, Zuris JA, Viswanathan R, Edelstein JN, Turk R, Thommandru B, Rube HT, Glenn SE, Collingwood MA, Bode NM, Beaudoin SF, Lele S, Scott SN, Wasko KM, Sexton S, Borges CM, Schubert MS, Kurgan GL, McNeill MS, Fernandez CA, Myer VE, Morgan RA, Behlke MA, Vakulskas CA. Zhang L, et al. Nat Commun. 2021 Jul 19;12(1):4500. doi: 10.1038/s41467-021-24770-w. Nat Commun. 2021. PMID: 34282150 Free PMC article. No abstract available.
Amplified genome editing by in vivo editor production.
Ngo W, Rosas-Rivera D, Wasko KM, Qiu L, Kang MH, Gogna S, Zeng J, Hooks MT, Wu JLY, Li Z, Doudna JA. Ngo W, et al. Among authors: wasko km. bioRxiv [Preprint]. 2026 Jan 13:2026.01.13.699115. doi: 10.64898/2026.01.13.699115. bioRxiv. 2026. PMID: 41648602 Free PMC article. Preprint.
Stepwise DNA unwinding gates TnpB genome-editing activity.
Zhou Z, Saffarian-Deemyad I, Shi H, Weiss T, Ur-Rehman MM, Vohra K, Skopintsev P, Yoon PH, Trinidad MI, Langeberg CJ, Kamalu M, Amerasekera J, Doherty EE, Aris KDP, Al-Sayyad N, Thornton BW, Weissman RF, Wasko KM, Esain-Garcia I, DeTurk EC, Savage DF, Jacobsen SE, Bryant Z, Doudna JA. Zhou Z, et al. Among authors: wasko km. bioRxiv [Preprint]. 2026 Jan 9:2026.01.09.698545. doi: 10.64898/2026.01.09.698545. bioRxiv. 2026. PMID: 41542533 Free PMC article. Preprint.
Targeted delivery of genome editors in vivo.
Ngo W, Wu JLY, Wasko KM, Doudna JA. Ngo W, et al. Among authors: wasko km. Nat Biotechnol. 2026 Jan;44(1):49-59. doi: 10.1038/s41587-025-02945-w. Epub 2026 Jan 12. Nat Biotechnol. 2026. PMID: 41526513 Free PMC article. Review.
Directed evolution expands CRISPR-Cas12a genome-editing capacity.
Ma E, Chen K, Shi H, Wasko KM, Esain-Garcia I, Trinidad MI, Zhou K, Ye J, Doudna JA. Ma E, et al. Among authors: wasko km. Nucleic Acids Res. 2025 Jul 8;53(13):gkaf649. doi: 10.1093/nar/gkaf649. Nucleic Acids Res. 2025. PMID: 40671523 Free PMC article.
26 results