Watabe T - Search Results

1

Strategic proposals for predicting drug-drug interactions during new drug development: based on sixteen deaths caused by interactions of the new antiviral sorivudine with 5-fluorouracil prodrugs.

Watabe T. Watabe T. J Toxicol Sci. 1996 Dec;21(5):299-300. doi: 10.2131/jts.21.5_299. J Toxicol Sci. 1996. PMID: 9035040 No abstract available.

2

[Molecular toxicological mechanism of the lethal interactions of the new antiviral drug, sorivudine, with 5-fluorouracil prodrugs and genetic deficiency of dihydropyrimidine dehydrogenase].

Watabe T, Ogura K, Nishiyama T. Watabe T, et al. Yakugaku Zasshi. 2002 Aug;122(8):527-35. doi: 10.1248/yakushi.122.527. Yakugaku Zasshi. 2002. PMID: 12187768 Review. Japanese.

3

Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.

Okuda H, Nishiyama T, Ogura K, Nagayama S, Ikeda K, Yamaguchi S, Nakamura Y, Kawaguchi K, Watabe T, Ogura Y. Okuda H, et al. Among authors: watabe t. Drug Metab Dispos. 1997 Feb;25(2):270-3. Drug Metab Dispos. 1997. PMID: 9029059 Corrected and republished.

4

Mechanism-based inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil in the presence of NADPH.

Nishiyama T, Ogura K, Okuda H, Suda K, Kato A, Watabe T. Nishiyama T, et al. Among authors: watabe t. Mol Pharmacol. 2000 May;57(5):899-905. Mol Pharmacol. 2000. PMID: 10779372

5

Prediction of in vivo drug-drug interactions based on mechanism-based inhibition from in vitro data: inhibition of 5-fluorouracil metabolism by (E)-5-(2-Bromovinyl)uracil.

Kanamitsu SI, Ito K, Okuda H, Ogura K, Watabe T, Muro K, Sugiyama Y. Kanamitsu SI, et al. Among authors: watabe t. Drug Metab Dispos. 2000 Apr;28(4):467-74. Drug Metab Dispos. 2000. PMID: 10725316 Clinical Trial.

6

A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.

Okuda H, Ogura K, Kato A, Takubo H, Watabe T. Okuda H, et al. Among authors: watabe t. J Pharmacol Exp Ther. 1998 Nov;287(2):791-9. J Pharmacol Exp Ther. 1998. PMID: 9808711

7

Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine.

Ogura K, Nishiyama T, Takubo H, Kato A, Okuda H, Arakawa K, Fukushima M, Nagayama S, Kawaguchi Y, Watabe T. Ogura K, et al. Among authors: watabe t. Cancer Lett. 1998 Jan 9;122(1-2):107-13. doi: 10.1016/s0304-3835(97)00377-7. Cancer Lett. 1998. PMID: 9464498

8

[Lethal drug interactions of the new antiviral, sorivudine, with anticancer prodrugs of 5-fluorouracil].

Watabe T, Okuda H, Ogura K. Watabe T, et al. Yakugaku Zasshi. 1997 Nov;117(10-11):910-21. doi: 10.1248/yakushi1947.117.10-11_910. Yakugaku Zasshi. 1997. PMID: 9414600 Review. Japanese.

9

Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.

Okuda H, Nishiyama T, Ogura K, Nagayama S, Ikeda K, Yamaguchi S, Nakamura Y, Kawaguchi Y, Watabe T. Okuda H, et al. Among authors: watabe t. Drug Metab Dispos. 1997 May;25(5):270-3. Drug Metab Dispos. 1997. PMID: 9152608

10

Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases.

Nishiyama T, Ogura K, Nakano H, Ohnuma T, Kaku T, Hiratsuka A, Muro K, Watabe T. Nishiyama T, et al. Among authors: watabe t. Biochem Pharmacol. 2002 May 15;63(10):1817-30. doi: 10.1016/s0006-2952(02)00994-2. Biochem Pharmacol. 2002. PMID: 12034366

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