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Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity.
Kamiyama A, Nakajima M, Han L, Wada K, Mizutani M, Tabuchi Y, Kojima-Yuasa A, Matsui-Yuasa I, Suzuki H, Fukuyama K, Watanabe B, Hiratake J. Kamiyama A, et al. Among authors: watanabe b. Bioorg Med Chem. 2016 Nov 1;24(21):5340-5352. doi: 10.1016/j.bmc.2016.08.050. Epub 2016 Aug 31. Bioorg Med Chem. 2016. PMID: 27622749
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