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Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement.
Okazawa A, Kanai T, Watanabe M, Yamazaki M, Inoue N, Ikeda M, Kurimoto M, Ishii H, Hibi T. Okazawa A, et al. Among authors: watanabe m. Am J Gastroenterol. 2002 Dec;97(12):3108-17. doi: 10.1111/j.1572-0241.2002.07107.x. Am J Gastroenterol. 2002. PMID: 12492197
Role of the innate immune system in the development of chronic colitis.
Kanai T, Ilyama R, Ishikura T, Uraushihara K, Totsuka T, Yamazaki M, Nakamuma T, Watanabe M. Kanai T, et al. Among authors: watanabe m. J Gastroenterol. 2002 Nov;37 Suppl 14:38-42. doi: 10.1007/BF03326411. J Gastroenterol. 2002. PMID: 12572864 Review.
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