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3,830 results
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Small molecules that target phosphorylation dependent protein-protein interaction.
Watanabe N, Osada H. Watanabe N, et al. Bioorg Med Chem. 2016 Aug 1;24(15):3246-54. doi: 10.1016/j.bmc.2016.03.023. Epub 2016 Mar 14. Bioorg Med Chem. 2016. PMID: 27017542 Review.
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.
Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H. Watanabe N, et al. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4419-24. doi: 10.1073/pnas.0307700101. Epub 2004 Mar 22. Proc Natl Acad Sci U S A. 2004. PMID: 15070733 Free PMC article.
Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.
Watanabe N, Arai H, Iwasaki J, Shiina M, Ogata K, Hunter T, Osada H. Watanabe N, et al. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11663-8. doi: 10.1073/pnas.0500410102. Epub 2005 Aug 5. Proc Natl Acad Sci U S A. 2005. PMID: 16085715 Free PMC article.
Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.
Watanabe N, Nishihara Y, Yamaguchi T, Koito A, Miyoshi H, Kakeya H, Osada H. Watanabe N, et al. FEBS Lett. 2006 May 15;580(11):2598-602. doi: 10.1016/j.febslet.2006.04.007. Epub 2006 Apr 19. FEBS Lett. 2006. PMID: 16631749
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.
Kanei-Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama KI, Ishii S. Kanei-Ishii C, et al. Among authors: watanabe n. J Biol Chem. 2008 Nov 7;283(45):30540-8. doi: 10.1074/jbc.M804340200. Epub 2008 Sep 2. J Biol Chem. 2008. PMID: 18765672 Free PMC article.
Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition.
Watanabe N, Sekine T, Takagi M, Iwasaki J, Imamoto N, Kawasaki H, Osada H. Watanabe N, et al. J Biol Chem. 2009 Jan 23;284(4):2344-53. doi: 10.1074/jbc.M805308200. Epub 2008 Nov 25. J Biol Chem. 2009. PMID: 19033445
Mapping of the interaction sites between Wee1 kinase and the regulatory beta-subunit of protein kinase CK2.
Olsen BB, Kreutzer JN, Watanabe N, Holm T, Guerra B. Olsen BB, et al. Among authors: watanabe n. Int J Oncol. 2010 May;36(5):1175-82. doi: 10.3892/ijo_00000600. Int J Oncol. 2010. PMID: 20372791
Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR.
Ong EB, Watanabe N, Saito A, Futamura Y, Abd El Galil KH, Koito A, Najimudin N, Osada H. Ong EB, et al. Among authors: watanabe n. J Biol Chem. 2011 Apr 22;286(16):14049-56. doi: 10.1074/jbc.M110.185397. Epub 2011 Feb 28. J Biol Chem. 2011. PMID: 21357691 Free PMC article.
Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy.
Watanabe N, Osada H. Watanabe N, et al. Curr Drug Targets. 2012 Dec;13(13):1654-8. doi: 10.2174/138945012803530035. Curr Drug Targets. 2012. PMID: 23030498 Review.
Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.
Futamura Y, Kawatani M, Kazami S, Tanaka K, Muroi M, Shimizu T, Tomita K, Watanabe N, Osada H. Futamura Y, et al. Among authors: watanabe n. Chem Biol. 2012 Dec 21;19(12):1620-30. doi: 10.1016/j.chembiol.2012.10.014. Chem Biol. 2012. PMID: 23261605
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