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Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage.
Yamamoto Y, Matsui J, Matsushima T, Obaishi H, Miyazaki K, Nakamura K, Tohyama O, Semba T, Yamaguchi A, Hoshi SS, Mimura F, Haneda T, Fukuda Y, Kamata JI, Takahashi K, Matsukura M, Wakabayashi T, Asada M, Nomoto KI, Watanabe T, Dezso Z, Yoshimatsu K, Funahashi Y, Tsuruoka A. Yamamoto Y, et al. Among authors: watanabe t. Vasc Cell. 2014 Sep 6;6:18. doi: 10.1186/2045-824X-6-18. eCollection 2014. Vasc Cell. 2014. PMID: 25197551 Free PMC article.
Novel sulfonamides as potential, systemically active antitumor agents.
Yoshino H, Ueda N, Niijima J, Sugumi H, Kotake Y, Koyanagi N, Yoshimatsu K, Asada M, Watanabe T, Nagasu T, et al. Yoshino H, et al. Among authors: watanabe t. J Med Chem. 1992 Jun 26;35(13):2496-7. doi: 10.1021/jm00091a018. J Med Chem. 1992. PMID: 1619621 No abstract available.
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