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More on 'the efficacy of antifolate antimalarial combinations in Africa'.
Watkins WM, Mberu EK, Winstanley PA, Plowe CV. Watkins WM, et al. Parasitol Today. 1999 Apr;15(4):131-2. doi: 10.1016/s0169-4758(99)01419-2. Parasitol Today. 1999. PMID: 10322331 No abstract available.
The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses.
Watkins WM, Mberu EK, Winstanley PA, Plowe CV. Watkins WM, et al. Parasitol Today. 1997 Dec;13(12):459-64. doi: 10.1016/s0169-4758(97)01124-1. Parasitol Today. 1997. PMID: 15275132
Here, Bill Watkins and colleagues analyse the relationship between the pharmacokinetic properties of two treatment combinations (PSD and chlorproguanil-dapsone) in vivo and the respective in vitro isobolograms for parasites with specific drug-resistance patterns. ...
Here, Bill Watkins and colleagues analyse the relationship between the pharmacokinetic properties of two treatment combinations (PSD …
Antimalarial dosing regimens and drug resistance.
Barnes KI, Watkins WM, White NJ. Barnes KI, et al. Among authors: watkins wm. Trends Parasitol. 2008 Mar;24(3):127-34. doi: 10.1016/j.pt.2007.11.008. Epub 2008 Feb 11. Trends Parasitol. 2008. PMID: 18262470 Review.
Tolerance is the key to understanding antimalarial drug resistance.
Hastings IM, Watkins WM. Hastings IM, et al. Trends Parasitol. 2006 Feb;22(2):71-7. doi: 10.1016/j.pt.2005.12.011. Epub 2006 Jan 10. Trends Parasitol. 2006. PMID: 16406706 Review.
Plasmodium falciparum: in vitro activity of sulfadoxine and dapsone in field isolates from Kenya: point mutations in dihydropteroate synthase may not be the only determinants in sulfa resistance.
Mberu EK, Nzila AM, Nduati E, Ross A, Monks SM, Kokwaro GO, Watkins WM, Hopkins Sibley C. Mberu EK, et al. Exp Parasitol. 2002 Jun-Jul;101(2-3):90-6. doi: 10.1016/s0014-4894(02)00108-x. Exp Parasitol. 2002. PMID: 12427462
The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug.
Kinyanjui SM, Mberu EK, Winstanley PA, Jacobus DP, Watkins WM. Kinyanjui SM, et al. Am J Trop Med Hyg. 1999 Jun;60(6):943-7. doi: 10.4269/ajtmh.1999.60.943. Am J Trop Med Hyg. 1999. PMID: 10403325
Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial.
Sulo J, Chimpeni P, Hatcher J, Kublin JG, Plowe CV, Molyneux ME, Marsh K, Taylor TE, Watkins WM, Winstanley PA. Sulo J, et al. Lancet. 2002 Oct 12;360(9340):1136-43. doi: 10.1016/s0140-6736(02)11198-6. Lancet. 2002. PMID: 12387962 Clinical Trial.
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