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ERα-associated translocations underlie oncogene amplifications in breast cancer.
Lee JJ, Jung YL, Cheong TC, Espejo Valle-Inclan J, Chu C, Gulhan DC, Ljungström V, Jin H, Viswanadham VV, Watson EV, Cortés-Ciriano I, Elledge SJ, Chiarle R, Pellman D, Park PJ. Lee JJ, et al. Among authors: watson ev. Nature. 2023 Jun;618(7967):1024-1032. doi: 10.1038/s41586-023-06057-w. Epub 2023 May 17. Nature. 2023. PMID: 37198482 Free PMC article.
p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism.
Laue K, Pozzi S, Zerbib J, Bertolio R, Eliezer Y, Cohen-Sharir Y, Winkler T, Caputo M, Ricci AA, Adler L, Khoury R, Longobardi G, Slutsky R, Leikin-Frenkel AI, Ovadia S, Lange K, Rustighi A, Piazza S, Sacconi A, Magesh RY, Keller FN, Berthelet J, Schäffer A, Saad R, Israeli Dangoor S, Szczepanowska K, Barshack I, Liao Y, Malitsky S, Brandis A, Broggini T, Czabanka M, Shi W, Merino D, Watson EV, Blandino G, Erez A, Ashery-Padan R, Medyouf H, Bertero L, Del Sal G, Satchi-Fainaro R, Ben-David U. Laue K, et al. Among authors: watson ev. Nat Genet. 2026 Jan;58(1):116-131. doi: 10.1038/s41588-025-02446-1. Epub 2025 Dec 29. Nat Genet. 2026. PMID: 41461910
PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors.
Chowdhury SR, Parikh CN, Kaur AN, DeMarco KD, Giwa HK, Mishra AK, Murphy KC, Zhou L, Ma B, Ye T, Li J, Liu H, Bai S, Johnson C, Simin K, Pitarresi JR, Zhu LJ, Watson EV, Kelliher MA, Green MR, Fitzgerald KA, Ruscetti M. Chowdhury SR, et al. Among authors: watson ev. Proc Natl Acad Sci U S A. 2025 Sep 30;122(39):e2514948122. doi: 10.1073/pnas.2514948122. Epub 2025 Sep 22. Proc Natl Acad Sci U S A. 2025. PMID: 40982692 Free PMC article.
13 results