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Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.
O'Brien A, Andrews SP, Baig AH, Bortolato A, Brown AJH, Brown GA, Brown SH, Christopher JA, Congreve M, Cooke RM, De Graaf C, Errey JC, Fieldhouse C, Jazayeri A, Marshall FH, Mason JS, Mobarec JC, Okrasa K, Steele KN, Southall SM, Teobald I, Watson SP, Weir M. O'Brien A, et al. Among authors: Watson SP. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126611. doi: 10.1016/j.bmcl.2019.08.015. Epub 2019 Aug 9. Bioorg Med Chem Lett. 2019. PMID: 31447084
Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2.
Bourne JH, Colicchia M, Di Y, Martin E, Slater A, Roumenina LT, Dimitrov JD, Watson SP, Rayes J. Bourne JH, et al. Among authors: Watson SP. Haematologica. 2020 Apr 30:haematol.2020.246488. doi: 10.3324/haematol.2020.246488. Online ahead of print. Haematologica. 2020. PMID: 32354867 Free article. No abstract available.
Editorial policy during the lockdown.
Watson SP, Harrison P, Halford GM. Watson SP, et al. Platelets. 2020 May 18;31(4):411. doi: 10.1080/09537104.2020.1758532. Epub 2020 Apr 25. Platelets. 2020. PMID: 32336199 No abstract available.
The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure.
Chauhan A, Sheriff L, Hussain MT, Webb GJ, Patten DA, Shepherd EL, Shaw R, Weston CJ, Haldar D, Bourke S, Bhandari R, Watson S, Adams DH, Watson SP, Lalor PF. Chauhan A, et al. Among authors: Watson S, Watson SP. Nat Commun. 2020 Apr 22;11(1):1939. doi: 10.1038/s41467-020-15584-3. Nat Commun. 2020. PMID: 32321925 Free PMC article.
Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis.
d'Alessandro E, Becker C, Bergmeier W, Bode C, Bourne JH, Brown H, Buller HR, Ten Cate-Hoek AJ, Ten Cate V, van Cauteren YJM, Cheung YFH, Cleuren A, Coenen D, Crijns HJGM, de Simone I, Dolleman SC, Klein CE, Fernandez DI, Granneman L, van T Hof A, Henke P, Henskens YMC, Huang J, Jennings LK, Jooss N, Karel M, van den Kerkhof D, Klok FA, Kremers B, Lämmle B, Leader A, Lundstrom A, Mackman N, Mannucci PM, Maqsood Z, van der Meijden PEJ, van Moorsel M, Moran LA, Morser J, van Mourik M, Navarro S, Neagoe RAI, Olie RH, van Paridon P, Posma J, Provenzale I, Reitsma PH, Scaf B, Schurgers L, Seelig J, Siegbahn A, Siegerink B, Soehnlein O, Soriano EM, Sowa MA, Spronk HMH, Storey RF, Tantiwong C, Veninga A, Wang X, Watson SP, Weitz J, Zeerleder SS, Ten Cate H; Scientific Reviewer Committee. d'Alessandro E, et al. Among authors: Watson SP. Thromb Haemost. 2020 Apr;120(4):538-564. doi: 10.1055/s-0040-1708035. Epub 2020 Apr 14. Thromb Haemost. 2020. PMID: 32289858
Lymphatic blood filling in CLEC-2-deficient mouse models.
Haining EJ, Lowe KL, Wichaiyo S, Kataru RP, Nagy Z, Kavanagh DP, Lax S, Di Y, Nieswandt B, Ho-Tin-Noé B, Mehrara BJ, Senis YA, Rayes J, Watson SP. Haining EJ, et al. Among authors: Watson SP. Platelets. 2020 Mar 4:1-16. doi: 10.1080/09537104.2020.1734784. Online ahead of print. Platelets. 2020. PMID: 32129691
The dual role of platelet-innate immune cell interactions in thrombo-inflammation.
Rayes J, Bourne JH, Brill A, Watson SP. Rayes J, et al. Among authors: Watson SP. Res Pract Thromb Haemost. 2019 Oct 17;4(1):23-35. doi: 10.1002/rth2.12266. eCollection 2020 Jan. Res Pract Thromb Haemost. 2019. PMID: 31989082 Free PMC article. Review.
Low dose Btk inhibitors selectively block platelet activation by CLEC-2.
Nicolson PLR, Nock SH, Hinds J, Garcia-Quintanilla L, Smith CW, Campos J, Brill A, Pike JA, Khan AO, Poulter NS, Kavanagh DM, Watson S, Watson CN, Clifford H, Huissoon AP, Pollitt AY, Eble JA, Pratt G, Watson SP, Hughes CE. Nicolson PLR, et al. Among authors: Watson S, Watson CN, Watson SP. Haematologica. 2020 Jan 16:haematol.2019.218545. doi: 10.3324/haematol.2019.218545. Online ahead of print. Haematologica. 2020. PMID: 31949019 Free article.
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