Watt AP - Search Results

1

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.

Evans DC, Watt AP, Nicoll-Griffith DA, Baillie TA. Evans DC, et al. Among authors: watt ap. Chem Res Toxicol. 2004 Jan;17(1):3-16. doi: 10.1021/tx034170b. Chem Res Toxicol. 2004. PMID: 14727914 Review.

2

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

Hop CE, Wang Y, Kumar S, Elipe MV, Raab CE, Dean DC, Poon GK, Keohane CA, Strauss J, Chiu SH, Curtis N, Elliott J, Gerhard U, Locker K, Morrison D, Mortishire-Smith R, Thomas S, Watt AP, Evans DC. Hop CE, et al. Among authors: watt ap. Drug Metab Dispos. 2002 Aug;30(8):937-43. doi: 10.1124/dmd.30.8.937. Drug Metab Dispos. 2002. PMID: 12124313

3

Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC-MS/MS.

Watt AP, Morrison D, Locker KL, Evans DC. Watt AP, et al. Anal Chem. 2000 Mar 1;72(5):979-84. doi: 10.1021/ac9906633. Anal Chem. 2000. PMID: 10739201

4

A quantitative high-throughput trapping assay as a measurement of potential for bioactivation.

Meneses-Lorente G, Sakatis MZ, Schulz-Utermoehl T, De Nardi C, Watt AP. Meneses-Lorente G, et al. Among authors: watt ap. Anal Biochem. 2006 Apr 15;351(2):266-72. doi: 10.1016/j.ab.2006.01.016. Epub 2006 Jan 30. Anal Biochem. 2006. PMID: 16473319

5

Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.

van Niel MB, Beer MS, Castro JL, Cheng SK, Evans DC, Heald A, Hitzel L, Hunt P, Mortishire-Smith R, O'Connor D, Watt AP, MacLeod AM. van Niel MB, et al. Among authors: watt ap. Bioorg Med Chem Lett. 1999 Nov 15;9(22):3243-8. doi: 10.1016/s0960-894x(99)00570-3. Bioorg Med Chem Lett. 1999. PMID: 10576696

6

A proteomic investigation of drug-induced steatosis in rat liver.

Meneses-Lorente G, Guest PC, Lawrence J, Muniappa N, Knowles MR, Skynner HA, Salim K, Cristea I, Mortishire-Smith R, Gaskell SJ, Watt A. Meneses-Lorente G, et al. Chem Res Toxicol. 2004 May;17(5):605-12. doi: 10.1021/tx034203n. Chem Res Toxicol. 2004. PMID: 15144217

7

Identification of early proteomic markers for hepatic steatosis.

Meneses-Lorente G, Watt A, Salim K, Gaskell SJ, Muniappa N, Lawrence J, Guest PC. Meneses-Lorente G, et al. Chem Res Toxicol. 2006 Aug;19(8):986-98. doi: 10.1021/tx060007f. Chem Res Toxicol. 2006. PMID: 16918237

8

Metabolite identification in drug discovery.

Watt AP, Mortishire-Smith RJ, Gerhard U, Thomas SR. Watt AP, et al. Curr Opin Drug Discov Devel. 2003 Jan;6(1):57-65. Curr Opin Drug Discov Devel. 2003. PMID: 12613277 Review.

9

Determination of drug concentrations in plasma by a highly automated, generic and flexible protein precipitation and liquid chromatography/tandem mass spectrometry method applicable to the drug discovery environment.

O'Connor D, Clarke DE, Morrison D, Watt AP. O'Connor D, et al. Among authors: watt ap. Rapid Commun Mass Spectrom. 2002;16(11):1065-71. doi: 10.1002/rcm.679. Rapid Commun Mass Spectrom. 2002. PMID: 11992509

10

Utility of long-term cultured human hepatocytes as an in vitro model for cytochrome p450 induction.

Meneses-Lorente G, Pattison C, Guyomard C, Chesné C, Heavens R, Watt AP, Sohal B. Meneses-Lorente G, et al. Among authors: watt ap. Drug Metab Dispos. 2007 Feb;35(2):215-20. doi: 10.1124/dmd.106.009423. Epub 2006 Nov 8. Drug Metab Dispos. 2007. PMID: 17093007

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