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In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.
Atack JR, Cook SM, Watt AP, Fletcher SR, Ragan CI. Atack JR, et al. Among authors: watt ap. J Neurochem. 1993 Feb;60(2):652-8. doi: 10.1111/j.1471-4159.1993.tb03197.x. J Neurochem. 1993. PMID: 8380439
Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.
Pike A, Cook SM, Watt AP, Scott-Stevens P, Rosahl TW, McKernan RM, Pym LJ, Guiblin A, Moyes C, Sohal B, Atack JR. Pike A, et al. Among authors: watt ap. Biopharm Drug Dispos. 2007 Sep;28(6):275-82. doi: 10.1002/bdd.553. Biopharm Drug Dispos. 2007. PMID: 17570124
Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.
van Niel MB, Collins I, Beer MS, Broughton HB, Cheng SK, Goodacre SC, Heald A, Locker KL, MacLeod AM, Morrison D, Moyes CR, O'Connor D, Pike A, Rowley M, Russell MG, Sohal B, Stanton JA, Thomas S, Verrier H, Watt AP, Castro JL. van Niel MB, et al. Among authors: watt ap. J Med Chem. 1999 Jun 17;42(12):2087-104. doi: 10.1021/jm981133m. J Med Chem. 1999. PMID: 10377215
2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution.
Cooper LC, Chicchi GG, Dinnell K, Elliott JM, Hollingworth GJ, Kurtz MM, Locker KL, Morrison D, Shaw DE, Tsao KL, Watt AP, Williams AR, Swain CJ. Cooper LC, et al. Among authors: watt ap. Bioorg Med Chem Lett. 2001 May 7;11(9):1233-6. doi: 10.1016/s0960-894x(01)00182-2. Bioorg Med Chem Lett. 2001. PMID: 11354384
Use of chiral liquid chromatography-tandem mass spectrometry to investigate the metabolism of racemic cholecystokinin-B antagonists.
Watt AP, Hitzel L, Morrison D, Locker KL. Watt AP, et al. J Chromatogr A. 2000 Oct 27;896(1-2):217-27. doi: 10.1016/s0021-9673(00)00575-6. J Chromatogr A. 2000. PMID: 11093657
3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.
Russell MG, Matassa VG, Pengilley RR, van Niel MB, Sohal B, Watt AP, Hitzel L, Beer MS, Stanton JA, Broughton HB, Castro JL. Russell MG, et al. Among authors: watt ap. J Med Chem. 1999 Dec 2;42(24):4981-5001. doi: 10.1021/jm9910021. J Med Chem. 1999. PMID: 10585208
3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.
Chambers MS, Street LJ, Goodacre S, Hobbs SC, Hunt P, Jelley RA, Matassa VG, Reeve AJ, Sternfeld F, Beer MS, Stanton JA, Rathbone D, Watt AP, MacLeod AM. Chambers MS, et al. Among authors: watt ap. J Med Chem. 1999 Feb 25;42(4):691-705. doi: 10.1021/jm980569z. J Med Chem. 1999. PMID: 10052976
Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor.
Sternfeld F, Guiblin AR, Jelley RA, Matassa VG, Reeve AJ, Hunt PA, Beer MS, Heald A, Stanton JA, Sohal B, Watt AP, Street LJ. Sternfeld F, et al. Among authors: watt ap. J Med Chem. 1999 Feb 25;42(4):677-90. doi: 10.1021/jm9805687. J Med Chem. 1999. PMID: 10052975
Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles.
Castro JL, Collins I, Russell MG, Watt AP, Sohal B, Rathbone D, Beer MS, Stanton JA. Castro JL, et al. Among authors: watt ap. J Med Chem. 1998 Jul 16;41(15):2667-70. doi: 10.1021/jm980204e. J Med Chem. 1998. PMID: 9667955 No abstract available.
Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.
Rowley M, Kulagowski JJ, Watt AP, Rathbone D, Stevenson GI, Carling RW, Baker R, Marshall GR, Kemp JA, Foster AC, Grimwood S, Hargreaves R, Hurley C, Saywell KL, Tricklebank MD, Leeson PD. Rowley M, et al. Among authors: watt ap. J Med Chem. 1997 Dec 5;40(25):4053-68. doi: 10.1021/jm970417o. J Med Chem. 1997. PMID: 9406596
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