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164 results
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Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth.
Pan Q, Chanthery Y, Liang WC, Stawicki S, Mak J, Rathore N, Tong RK, Kowalski J, Yee SF, Pacheco G, Ross S, Cheng Z, Le Couter J, Plowman G, Peale F, Koch AW, Wu Y, Bagri A, Tessier-Lavigne M, Watts RJ. Pan Q, et al. Among authors: watts rj. Cancer Cell. 2007 Jan;11(1):53-67. doi: 10.1016/j.ccr.2006.10.018. Cancer Cell. 2007. PMID: 17222790
Therapeutic antibody targeting of individual Notch receptors.
Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW. Wu Y, et al. Among authors: watts rj. Nature. 2010 Apr 15;464(7291):1052-7. doi: 10.1038/nature08878. Nature. 2010. PMID: 20393564
A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo.
Atwal JK, Chen Y, Chiu C, Mortensen DL, Meilandt WJ, Liu Y, Heise CE, Hoyte K, Luk W, Lu Y, Peng K, Wu P, Rouge L, Zhang Y, Lazarus RA, Scearce-Levie K, Wang W, Wu Y, Tessier-Lavigne M, Watts RJ. Atwal JK, et al. Among authors: watts rj. Sci Transl Med. 2011 May 25;3(84):84ra43. doi: 10.1126/scitranslmed.3002254. Sci Transl Med. 2011. PMID: 21613622
Transferrin antibodies into the brain.
Dennis MS, Watts RJ. Dennis MS, et al. Among authors: watts rj. Neuropsychopharmacology. 2012 Jan;37(1):302-3. doi: 10.1038/npp.2011.196. Neuropsychopharmacology. 2012. PMID: 22157868 Free PMC article. No abstract available.
Death receptors DR6 and TROY regulate brain vascular development.
Tam SJ, Richmond DL, Kaminker JS, Modrusan Z, Martin-McNulty B, Cao TC, Weimer RM, Carano RA, van Bruggen N, Watts RJ. Tam SJ, et al. Among authors: watts rj. Dev Cell. 2012 Feb 14;22(2):403-17. doi: 10.1016/j.devcel.2011.11.018. Dev Cell. 2012. PMID: 22340501
Pharmacokinetic and pharmacodynamic analysis of circulating biomarkers of anti-NRP1, a novel antiangiogenesis agent, in two phase I trials in patients with advanced solid tumors.
Xin Y, Li J, Wu J, Kinard R, Weekes CD, Patnaik A, Lorusso P, Brachmann R, Tong RK, Yan Y, Watts R, Bai S, Hegde PS. Xin Y, et al. Clin Cancer Res. 2012 Nov 1;18(21):6040-8. doi: 10.1158/1078-0432.CCR-12-1652. Epub 2012 Sep 7. Clin Cancer Res. 2012. PMID: 22962439 Clinical Trial.
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