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173 results

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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, Henne K, Leyns CE, Gallardo G, Ulrich JD, Sullivan PM, Lerner EP, Hudry E, Sweeney ZK, Dennis MS, Hyman BT, Watts RJ, Holtzman DM. Liao F, et al. Among authors: watts rj. J Clin Invest. 2018 May 1;128(5):2144-2155. doi: 10.1172/JCI96429. Epub 2018 Mar 30. J Clin Invest. 2018. PMID: 29600961 Free PMC article.
Transferrin antibodies into the brain.
Dennis MS, Watts RJ. Dennis MS, et al. Among authors: watts rj. Neuropsychopharmacology. 2012 Jan;37(1):302-3. doi: 10.1038/npp.2011.196. Neuropsychopharmacology. 2012. PMID: 22157868 Free PMC article. No abstract available.
Bispecific antibodies for delivery into the brain.
Watts RJ, Dennis MS. Watts RJ, et al. Curr Opin Chem Biol. 2013 Jun;17(3):393-9. doi: 10.1016/j.cbpa.2013.03.023. Epub 2013 Apr 6. Curr Opin Chem Biol. 2013. PMID: 23570979 Review.
Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.
Couch JA, Yu YJ, Zhang Y, Tarrant JM, Fuji RN, Meilandt WJ, Solanoy H, Tong RK, Hoyte K, Luk W, Lu Y, Gadkar K, Prabhu S, Ordonia BA, Nguyen Q, Lin Y, Lin Z, Balazs M, Scearce-Levie K, Ernst JA, Dennis MS, Watts RJ. Couch JA, et al. Among authors: watts rj. Sci Transl Med. 2013 May 1;5(183):183ra57, 1-12. doi: 10.1126/scitranslmed.3005338. Sci Transl Med. 2013. PMID: 23636093
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.
Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, Ernst JA, Scearce-Levie K, Couch JA, Dennis MS, Watts RJ. Yu YJ, et al. Among authors: watts rj. Sci Transl Med. 2014 Nov 5;6(261):261ra154. doi: 10.1126/scitranslmed.3009835. Sci Transl Med. 2014. PMID: 25378646
The blood-brain barrier's gut check.
Bien-Ly N, Watts RJ. Bien-Ly N, et al. Among authors: watts rj. Sci Transl Med. 2014 Nov 19;6(263):263fs46. doi: 10.1126/scitranslmed.aaa2543. Sci Transl Med. 2014. PMID: 25411469 No abstract available.
Dissecting gene expression at the blood-brain barrier.
Huntley MA, Bien-Ly N, Daneman R, Watts RJ. Huntley MA, et al. Among authors: watts rj. Front Neurosci. 2014 Nov 6;8:355. doi: 10.3389/fnins.2014.00355. eCollection 2014. Front Neurosci. 2014. PMID: 25414634 Free PMC article. Review.
173 results