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Recombinant activated factor VII increases survival time in a model of incompressible arterial hemorrhage in the anesthetized pig.
Sapsford W, Watts S, Cooper G, Kirkman E. Sapsford W, et al. Among authors: watts s. J Trauma. 2007 Apr;62(4):868-79. doi: 10.1097/ta.0b013e318034204b. J Trauma. 2007. PMID: 17426541
A proactive approach to the coagulopathy of trauma: the rationale and guidelines for treatment.
Kirkman E, Watts S, Hodgetts T, Mahoney P, Rawlinson S, Midwinter M. Kirkman E, et al. Among authors: watts s. J R Army Med Corps. 2007 Dec;153(4):302-6. doi: 10.1136/jramc-153-04-17. J R Army Med Corps. 2007. PMID: 18619168 No abstract available.
Development of a large animal model for investigating resuscitation after blast and hemorrhage.
Garner JP, Watts S, Parry C, Bird J, Kirkman E. Garner JP, et al. Among authors: watts s. World J Surg. 2009 Oct;33(10):2194-202. doi: 10.1007/s00268-009-0105-4. World J Surg. 2009. PMID: 19653034
Prolonged permissive hypotensive resuscitation is associated with poor outcome in primary blast injury with controlled hemorrhage.
Garner J, Watts S, Parry C, Bird J, Cooper G, Kirkman E. Garner J, et al. Among authors: watts s. Ann Surg. 2010 Jun;251(6):1131-9. doi: 10.1097/SLA.0b013e3181e00fcb. Ann Surg. 2010. PMID: 20485127
METHODS: Terminally anesthetized pigs were divided into 4 groups and subjected to either air-blast injury (B) or no blast (S). ...(n = 6 in each B and n = 8 in each S subgroup). RESULTS: Survival time was significantly shorter with Hypot (P<0.0001 Peto log rank). …
METHODS: Terminally anesthetized pigs were divided into 4 groups and subjected to either air-blast injury (B) or no blast (S). ...(n …
Blast injury research models.
Kirkman E, Watts S, Cooper G. Kirkman E, et al. Among authors: watts s. Philos Trans R Soc Lond B Biol Sci. 2011 Jan 27;366(1562):144-59. doi: 10.1098/rstb.2010.0240. Philos Trans R Soc Lond B Biol Sci. 2011. PMID: 21149352 Free PMC article. Review.
Targeted resuscitation improves coagulation and outcome.
Doran CM, Doran CA, Woolley T, Carter A, Male K, Midwinter MJ, Mahoney PF, Watts S, Kirkman E. Doran CM, et al. Among authors: watts s. J Trauma Acute Care Surg. 2012 Apr;72(4):835-43. doi: 10.1097/TA.0b013e318248347b. J Trauma Acute Care Surg. 2012. PMID: 22491594
A pre-clinical evaluation of silver, iodine and Manuka honey based dressings in a model of traumatic extremity wounds contaminated with Staphylococcus aureus.
Guthrie HC, Martin KR, Taylor C, Spear AM, Whiting R, Macildowie S, Clasper JC, Watts SA. Guthrie HC, et al. Among authors: watts sa. Injury. 2014 Aug;45(8):1171-8. doi: 10.1016/j.injury.2014.05.007. Epub 2014 May 17. Injury. 2014. PMID: 24908627
The primary outcome was a statistically significant reduction (p<0.05) in tissue S. aureus at 7 days post-injury. Secondary outcome measurements included bacteraemias, observational data, whole blood determination, ELISA for plasma biomarkers, PCR array analysis of woun …
The primary outcome was a statistically significant reduction (p<0.05) in tissue S. aureus at 7 days post-injury. Secondary outcom …
Haemodynamic changes in trauma.
Kirkman E, Watts S. Kirkman E, et al. Among authors: watts s. Br J Anaesth. 2014 Aug;113(2):266-75. doi: 10.1093/bja/aeu232. Br J Anaesth. 2014. PMID: 25038158 Review.
Its haemodynamic response underpins the patient's initial ability to survive, and the response to treatment and subsequent morbidity and resolution. ...
Its haemodynamic response underpins the patient's initial ability to survive, and the response to treatment and subsequent morbidity …
Evaluation of Prehospital Blood Products to Attenuate Acute Coagulopathy of Trauma in a Model of Severe Injury and Shock in Anesthetized Pigs.
Watts S, Nordmann G, Brohi K, Midwinter M, Woolley T, Gwyther R, Wilson C, Poon H, Kirkman E. Watts S, et al. Shock. 2015 Aug;44 Suppl 1(Suppl 1):138-48. doi: 10.1097/SHK.0000000000000409. Shock. 2015. PMID: 26177017 Free PMC article.
Modeling Acute Traumatic Hemorrhagic Shock Injury: Challenges and Guidelines for Preclinical Studies.
Tremoleda JL, Watts SA, Reynolds PS, Thiemermann C, Brohi K. Tremoleda JL, et al. Among authors: watts sa. Shock. 2017 Dec;48(6):610-623. doi: 10.1097/SHK.0000000000000901. Shock. 2017. PMID: 28509685 Review.
Trauma is responsible for a large proportion of the world's burden of disease, and is by far the biggest killer of young adults. ...
Trauma is responsible for a large proportion of the world's burden of disease, and is by far the biggest killer of young adults. ...
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