Waxman DJ - Search Results

1

Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer.

Roy P, Waxman DJ. Roy P, et al. Among authors: waxman dj. Toxicol In Vitro. 2006 Mar;20(2):176-86. doi: 10.1016/j.tiv.2005.06.046. Epub 2005 Nov 15. Toxicol In Vitro. 2006. PMID: 16293390 Review.

2

Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy.

Günther M, Waxman DJ, Wagner E, Ogris M. Günther M, et al. Among authors: waxman dj. Cancer Gene Ther. 2006 Aug;13(8):771-9. doi: 10.1038/sj.cgt.7700955. Epub 2006 Mar 17. Cancer Gene Ther. 2006. PMID: 16543915

3

Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model.

Chen CS, Jounaidi Y, Su T, Waxman DJ. Chen CS, et al. Among authors: waxman dj. Cancer Gene Ther. 2007 Dec;14(12):935-44. doi: 10.1038/sj.cgt.7701092. Epub 2007 Sep 14. Cancer Gene Ther. 2007. PMID: 17853921 Free PMC article.

4

Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.

Sun L, Chen CS, Waxman DJ, Liu H, Halpert JR, Kumar S. Sun L, et al. Among authors: waxman dj. Arch Biochem Biophys. 2007 Feb 15;458(2):167-74. doi: 10.1016/j.abb.2006.12.021. Epub 2007 Jan 8. Arch Biochem Biophys. 2007. PMID: 17254539 Free PMC article.

5

Cancer chemotherapy and drug metabolism.

Riddick DS, Lee C, Ramji S, Chinje EC, Cowen RL, Williams KJ, Patterson AV, Stratford IJ, Morrow CS, Townsend AJ, Jounaidi Y, Chen CS, Su T, Lu H, Schwartz PS, Waxman DJ. Riddick DS, et al. Among authors: waxman dj. Drug Metab Dispos. 2005 Aug;33(8):1083-96. doi: 10.1124/dmd.105.004374. Drug Metab Dispos. 2005. PMID: 16049130

6

Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide.

Kumar S, Chen CS, Waxman DJ, Halpert JR. Kumar S, et al. Among authors: waxman dj. J Biol Chem. 2005 May 20;280(20):19569-75. doi: 10.1074/jbc.M500158200. Epub 2005 Mar 17. J Biol Chem. 2005. PMID: 15774478

7

Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450.

Chen CS, Jounaidi Y, Waxman DJ. Chen CS, et al. Among authors: waxman dj. Drug Metab Dispos. 2005 Sep;33(9):1261-7. doi: 10.1124/dmd.105.004788. Epub 2005 May 26. Drug Metab Dispos. 2005. PMID: 15919850

8

Role of cytochrome P450 in oxazaphosphorine metabolism. Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochromes P450.

Yu L, Waxman DJ. Yu L, et al. Among authors: waxman dj. Drug Metab Dispos. 1996 Nov;24(11):1254-62. Drug Metab Dispos. 1996. PMID: 8937861

9

Adenoviral vectors for prodrug activation-based gene therapy for cancer.

Doloff JC, Waxman DJ. Doloff JC, et al. Among authors: waxman dj. Anticancer Agents Med Chem. 2014 Jan;14(1):115-26. doi: 10.2174/18715206113139990309. Anticancer Agents Med Chem. 2014. PMID: 23869779 Free PMC article. Review.

10

A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition.

Gu J, Chen CS, Wei Y, Fang C, Xie F, Kannan K, Yang W, Waxman DJ, Ding X. Gu J, et al. Among authors: waxman dj. J Pharmacol Exp Ther. 2007 Apr;321(1):9-17. doi: 10.1124/jpet.106.118240. Epub 2007 Jan 11. J Pharmacol Exp Ther. 2007. PMID: 17218484

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