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Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane.
Abo A, Webb MR, Grogan A, Segal AW. Abo A, et al. Among authors: webb mr. Biochem J. 1994 Mar 15;298 Pt 3(Pt 3):585-91. doi: 10.1042/bj2980585. Biochem J. 1994. PMID: 8141770 Free PMC article.
Fluorescence detection of GDP in real time with the reagentless biosensor rhodamine-ParM.
Kunzelmann S, Webb MR. Kunzelmann S, et al. Among authors: webb mr. Biochem J. 2011 Nov 15;440(1):43-9. doi: 10.1042/BJ20110349. Biochem J. 2011. PMID: 21812760 Free PMC article.
The mechanism of Ras GTPase activation by neurofibromin.
Phillips RA, Hunter JL, Eccleston JF, Webb MR. Phillips RA, et al. Among authors: webb mr. Biochemistry. 2003 Apr 8;42(13):3956-65. doi: 10.1021/bi027316z. Biochemistry. 2003. PMID: 12667087
Role of magnesium in nucleotide exchange on the small G protein rac investigated using novel fluorescent Guanine nucleotide analogues.
Shutes A, Phillips RA, Corrie JE, Webb MR. Shutes A, et al. Among authors: webb mr. Biochemistry. 2002 Mar 19;41(11):3828-35. doi: 10.1021/bi0119464. Biochemistry. 2002. PMID: 11888302
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.
Hirshberg M, Stockley RW, Dodson G, Webb MR. Hirshberg M, et al. Among authors: webb mr. Nat Struct Biol. 1997 Feb;4(2):147-52. doi: 10.1038/nsb0297-147. Nat Struct Biol. 1997. PMID: 9033596
Interaction of GTPase activating proteins (GAPs) with p21ras measured by a novel fluorescence anisotropy method. Essential role of Arg-903 of GAP in activation of GTP hydrolysis on p21ras.
Brownbridge GG, Lowe PN, Moore KJ, Skinner RH, Webb MR. Brownbridge GG, et al. Among authors: webb mr. J Biol Chem. 1993 May 25;268(15):10914-9. J Biol Chem. 1993. PMID: 8496156
Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: studies with a fluorescent GTP analogue.
Moore KJ, Webb MR, Eccleston JF. Moore KJ, et al. Among authors: webb mr. Biochemistry. 1993 Jul 27;32(29):7451-9. doi: 10.1021/bi00080a016. Biochemistry. 1993. PMID: 8338843
Fluorescence approaches to the study of the p21ras GTPase mechanism.
Eccleston JF, Moore KJ, Brownbridge GG, Webb MR, Lowe PN. Eccleston JF, et al. Among authors: webb mr. Biochem Soc Trans. 1991 Apr;19(2):432-7. doi: 10.1042/bst0190432. Biochem Soc Trans. 1991. PMID: 1889625 Review.
Kinetic analysis of the hydrolysis of GTP by p21N-ras. The basal GTPase mechanism.
Neal SE, Eccleston JF, Hall A, Webb MR. Neal SE, et al. Among authors: webb mr. J Biol Chem. 1988 Dec 25;263(36):19718-22. J Biol Chem. 1988. PMID: 2848838
Interaction of GTPase-activating protein with p21ras, measured using a continuous assay for inorganic phosphate release.
Webb MR, Hunter JL. Webb MR, et al. Biochem J. 1992 Oct 15;287 ( Pt 2)(Pt 2):555-9. doi: 10.1042/bj2870555. Biochem J. 1992. PMID: 1445214 Free PMC article.
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