Webb P - Search Results

1

Molecular dynamics simulations of ligand dissociation from thyroid hormone receptors: evidence of the likeliest escape pathway and its implications for the design of novel ligands.

Martínez L, Webb P, Polikarpov I, Skaf MS. Martínez L, et al. Among authors: webb p. J Med Chem. 2006 Jan 12;49(1):23-6. doi: 10.1021/jm050805n. J Med Chem. 2006. PMID: 16392786

2

Molecular dynamics simulations reveal multiple pathways of ligand dissociation from thyroid hormone receptors.

Martínez L, Sonoda MT, Webb P, Baxter JD, Skaf MS, Polikarpov I. Martínez L, et al. Among authors: webb p. Biophys J. 2005 Sep;89(3):2011-23. doi: 10.1529/biophysj.105.063818. Epub 2005 Jun 24. Biophys J. 2005. PMID: 15980170 Free PMC article.

3

Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.

Bleicher L, Aparicio R, Nunes FM, Martinez L, Gomes Dias SM, Figueira AC, Santos MA, Venturelli WH, da Silva R, Donate PM, Neves FA, Simeoni LA, Baxter JD, Webb P, Skaf MS, Polikarpov I. Bleicher L, et al. Among authors: webb p. BMC Struct Biol. 2008 Jan 31;8:8. doi: 10.1186/1472-6807-8-8. BMC Struct Biol. 2008. PMID: 18237438 Free PMC article.

4

Ligand dissociation from estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations.

Sonoda MT, Martínez L, Webb P, Skaf MS, Polikarpov I. Sonoda MT, et al. Among authors: webb p. Mol Endocrinol. 2008 Jul;22(7):1565-78. doi: 10.1210/me.2007-0501. Epub 2008 Apr 10. Mol Endocrinol. 2008. PMID: 18403716 Free PMC article.

5

Gaining ligand selectivity in thyroid hormone receptors via entropy.

Martínez L, Nascimento AS, Nunes FM, Phillips K, Aparicio R, Dias SM, Figueira AC, Lin JH, Nguyen P, Apriletti JW, Neves FA, Baxter JD, Webb P, Skaf MS, Polikarpov I. Martínez L, et al. Among authors: webb p. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20717-22. doi: 10.1073/pnas.0911024106. Epub 2009 Nov 19. Proc Natl Acad Sci U S A. 2009. PMID: 19926848 Free PMC article.

6

Helix 12 dynamics and thyroid hormone receptor activity: experimental and molecular dynamics studies of Ile280 mutants.

Souza PC, Barra GB, Velasco LF, Ribeiro IC, Simeoni LA, Togashi M, Webb P, Neves FA, Skaf MS, Martínez L, Polikarpov I. Souza PC, et al. Among authors: webb p. J Mol Biol. 2011 Oct 7;412(5):882-93. doi: 10.1016/j.jmb.2011.04.014. Epub 2011 Apr 21. J Mol Biol. 2011. PMID: 21530542 Free article.

7

Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange.

Figueira AC, Saidemberg DM, Souza PC, Martínez L, Scanlan TS, Baxter JD, Skaf MS, Palma MS, Webb P, Polikarpov I. Figueira AC, et al. Among authors: webb p. Mol Endocrinol. 2011 Jan;25(1):15-31. doi: 10.1210/me.2010-0202. Epub 2010 Nov 24. Mol Endocrinol. 2011. PMID: 21106879 Free PMC article.

8

Identification of a new hormone-binding site on the surface of thyroid hormone receptor.

Souza PC, Puhl AC, Martínez L, Aparício R, Nascimento AS, Figueira AC, Nguyen P, Webb P, Skaf MS, Polikarpov I. Souza PC, et al. Among authors: webb p. Mol Endocrinol. 2014 Apr;28(4):534-45. doi: 10.1210/me.2013-1359. Epub 2014 Feb 19. Mol Endocrinol. 2014. PMID: 24552590 Free PMC article.

9

Human thyroid receptor forms tetramers in solution, which dissociate into dimers upon ligand binding.

Figueira AC, Dias SM, Santos MA, Apriletti JW, Baxter JD, Webb P, Neves FA, Simeoni LA, Ribeiro RC, Polikarpov I. Figueira AC, et al. Among authors: webb p. Cell Biochem Biophys. 2006;44(3):453-62. doi: 10.1385/CBB:44:3:453. Cell Biochem Biophys. 2006. PMID: 16679533

10

Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function.

Nascimento AS, Dias SM, Nunes FM, Aparício R, Ambrosio AL, Bleicher L, Figueira AC, Santos MA, de Oliveira Neto M, Fischer H, Togashi M, Craievich AF, Garratt RC, Baxter JD, Webb P, Polikarpov I. Nascimento AS, et al. Among authors: webb p. J Mol Biol. 2006 Jul 14;360(3):586-98. doi: 10.1016/j.jmb.2006.05.008. Epub 2006 May 19. J Mol Biol. 2006. PMID: 16781732

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