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Functional investigation of the coronary artery disease gene SVEP1.
Winkler MJ, Müller P, Sharifi AM, Wobst J, Winter H, Mokry M, Ma L, van der Laan SW, Pang S, Miritsch B, Hinterdobler J, Werner J, Stiller B, Güldener U, Webb TR, Asselbergs FW, Björkegren JLM, Maegdefessel L, Schunkert H, Sager HB, Kessler T. Winkler MJ, et al. Among authors: webb tr. Basic Res Cardiol. 2020 Nov 13;115(6):67. doi: 10.1007/s00395-020-00828-6. Basic Res Cardiol. 2020. PMID: 33185739 Free PMC article.
Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation from Genome Sequencing.
Carss KJ, Baranowska AA, Armisen J, Webb TR, Hamby SE, Premawardhana D, Al-Hussaini A, Wood A, Wang Q, Deevi SVV, Vitsios D, Lewis SH, Kotecha D, Bouatia-Naji N, Hesselson S, Iismaa SE, Tarr I, McGrath-Cadell L, Muller DW, Dunwoodie SL, Fatkin D, Graham RM, Giannoulatou E, Samani NJ, Petrovski S, Haefliger C, Adlam D. Carss KJ, et al. Among authors: webb tr. Circ Genom Precis Med. 2020 Oct 30. doi: 10.1161/CIRCGEN.120.003030. Online ahead of print. Circ Genom Precis Med. 2020. PMID: 33125268
Genetic Associations With Plasma Angiotensin Converting Enzyme 2 Concentration: Potential Relevance to COVID-19 Risk.
Nelson CP, Sama IE, Codd V, Webb TR, Ye S, Lang CC, Voors AA, Ng LL, Samani NJ. Nelson CP, et al. Among authors: webb tr. Circulation. 2020 Sep 15;142(11):1117-1119. doi: 10.1161/CIRCULATIONAHA.120.049007. Epub 2020 Jul 7. Circulation. 2020. PMID: 32795093 No abstract available.
Novel loss of function mutation in NOTCH1 in a family with bicuspid aortic valve, ventricular septal defect, thoracic aortic aneurysm, and aortic valve stenosis.
Debiec R, Hamby SE, Jones PD, Coolman S, Asiani M, Kharodia S, Skinner GJ, Samani NJ, Webb TR, Bolger A. Debiec R, et al. Among authors: webb tr. Mol Genet Genomic Med. 2020 Jul 27;8(10):e1437. doi: 10.1002/mgg3.1437. Online ahead of print. Mol Genet Genomic Med. 2020. PMID: 32720365 Free PMC article.
Rare Loss-of-function Mutations of PTGIR are enriched in Fibromuscular Dysplasia.
Georges A, Albuisson J, Berrandou T, Dupré D, Lorthioir A, D'Escamard V, Di Narzo AF, Kadian-Dodov D, Olin JW, Warchol-Celinska E, Prejbisz A, Januszewicz A, Bruneval P, Baranowska AA, Webb TR, Hamby SE, Samani NJ, Adlam D, Fendrikova-Mahlay N, Hazen S, Wang Y, Yang ML, Hunker K, Combaret N, Motreff P, Chédid A, Fiquet B, Plouin PF, Mousseaux E, Azarine A, Amar L, Azizi M, Gornik HL, Ganesh SK, Kovacic JC, Jeunemaitre X, Bouatia-Naji N. Georges A, et al. Among authors: webb tr. Cardiovasc Res. 2020 Jun 12:cvaa161. doi: 10.1093/cvr/cvaa161. Online ahead of print. Cardiovasc Res. 2020. PMID: 32531060
An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications.
Shi Y, Bray W, Smith AJ, Zhou W, Calaoagan J, Lagisetti C, Sambucetti L, Crews P, Lokey RS, Webb TR. Shi Y, et al. Among authors: webb tr. PLoS One. 2020 May 29;15(5):e0233672. doi: 10.1371/journal.pone.0233672. eCollection 2020. PLoS One. 2020. PMID: 32469945 Free PMC article.
FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease-Associated Genetic Variant and Influences Monocyte Transendothelial Migration.
Yang X, Yang W, McVey DG, Zhao G, Hu J, Poston RN, Ren M, Willeit K, Coassin S, Willeit J, Webb TR, Samani NJ, Mayr M, Kiechl S, Ye S. Yang X, et al. Among authors: webb tr. J Am Heart Assoc. 2020 Feb 18;9(4):e014333. doi: 10.1161/JAHA.119.014333. Epub 2020 Feb 11. J Am Heart Assoc. 2020. PMID: 32067586 Free PMC article.
Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis.
Pu X, Chan K, Yang W, Xiao Q, Zhang L, Moore AD, Liu C, Webb TR, Caulfield MJ, Samani NJ, Zhu J, Ye S. Pu X, et al. Among authors: webb tr. Atherosclerosis. 2020 Mar;296:11-17. doi: 10.1016/j.atherosclerosis.2020.01.015. Epub 2020 Jan 21. Atherosclerosis. 2020. PMID: 32005000
HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis.
Aravani D, Morris GE, Jones PD, Tattersall HK, Karamanavi E, Kaiser MA, Kostogrys RB, Ghaderi Najafabadi M, Andrews SL, Nath M, Ye S, Stringer EJ, Samani NJ, Webb TR. Aravani D, et al. Among authors: webb tr. Circulation. 2019 Aug 6;140(6):500-513. doi: 10.1161/CIRCULATIONAHA.119.041059. Epub 2019 Jun 5. Circulation. 2019. PMID: 31163988 Free PMC article.
The future of canine glaucoma therapy.
Komáromy AM, Bras D, Esson DW, Fellman RL, Grozdanic SD, Kagemann L, Miller PE, Moroi SE, Plummer CE, Sapienza JS, Storey ES, Teixeira LB, Toris CB, Webb TR. Komáromy AM, et al. Among authors: webb tr. Vet Ophthalmol. 2019 Sep;22(5):726-740. doi: 10.1111/vop.12678. Epub 2019 May 20. Vet Ophthalmol. 2019. PMID: 31106969 Free PMC article. Review.
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