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18 results
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In vitro-in vivo extrapolation of hepatic clearance involving active uptake: theoretical and experimental aspects.
Webborn PJ, Parker AJ, Denton RL, Riley RJ. Webborn PJ, et al. Xenobiotica. 2007 Oct-Nov;37(10-11):1090-109. doi: 10.3109/00498250701557266. Xenobiotica. 2007. PMID: 17968738 Review.
Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes.
Grime K, Webborn PJ, Riley RJ. Grime K, et al. Among authors: webborn pj. Drug Metab Dispos. 2008 Aug;36(8):1670-8. doi: 10.1124/dmd.108.021055. Epub 2008 May 12. Drug Metab Dispos. 2008. PMID: 18474678
The right compound in the right assay at the right time: an integrated discovery DMPK strategy.
Ballard P, Brassil P, Bui KH, Dolgos H, Petersson C, Tunek A, Webborn PJ. Ballard P, et al. Among authors: webborn pj. Drug Metab Rev. 2012 Aug;44(3):224-52. doi: 10.3109/03602532.2012.691099. Epub 2012 Jun 15. Drug Metab Rev. 2012. PMID: 22697420 Review.
Hepatic uptake in the dog: comparison of uptake in hepatocytes and human embryonic kidney cells expressing dog organic anion-transporting polypeptide 1B4.
Wilby AJ, Maeda K, Courtney PF, Debori Y, Webborn PJ, Kitamura Y, Kusuhara H, Riley RJ, Sugiyama Y. Wilby AJ, et al. Among authors: webborn pj. Drug Metab Dispos. 2011 Dec;39(12):2361-9. doi: 10.1124/dmd.111.041814. Epub 2011 Sep 22. Drug Metab Dispos. 2011. PMID: 21940906
Impact of hepatic uptake transporters on pharmacokinetics and drug-drug interactions: use of assays and models for decision making in the pharmaceutical industry.
Soars MG, Webborn PJ, Riley RJ. Soars MG, et al. Among authors: webborn pj. Mol Pharm. 2009 Nov-Dec;6(6):1662-77. doi: 10.1021/mp800246x. Mol Pharm. 2009. PMID: 19402709 Review.
Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo.
Soars MG, Grime K, Sproston JL, Webborn PJ, Riley RJ. Soars MG, et al. Among authors: webborn pj. Drug Metab Dispos. 2007 Jun;35(6):859-65. doi: 10.1124/dmd.106.014464. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344337
Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes.
Paine SW, Parker AJ, Gardiner P, Webborn PJ, Riley RJ. Paine SW, et al. Among authors: webborn pj. Drug Metab Dispos. 2008 Jul;36(7):1365-74. doi: 10.1124/dmd.107.019455. Epub 2008 Apr 21. Drug Metab Dispos. 2008. PMID: 18426955
Robust assessment of statistical significance in the use of unbound/intrinsic pharmacokinetic parameters in quantitative structure-pharmacokinetic relationships with lipophilicity.
Davis AM, Webborn PJ, Salt DW. Davis AM, et al. Among authors: webborn pj. Drug Metab Dispos. 2000 Feb;28(2):103-6. Drug Metab Dispos. 2000. PMID: 10640503
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.
Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, Leff P, Lewis RJ, Martin BP, McGinnity DF, Mortimore MP, Paine SW, Pairaudeau G, Patel A, Rigby AJ, Riley RJ, Teobald BJ, Tomlinson W, Webborn PJ, Willis PA. Springthorpe B, et al. Among authors: webborn pj. Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8. doi: 10.1016/j.bmcl.2007.07.057. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17827008
Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.
Furber M, Alcaraz L, Bent JE, Beyerbach A, Bowers K, Braddock M, Caffrey MV, Cladingboel D, Collington J, Donald DK, Fagura M, Ince F, Kinchin EC, Laurent C, Lawson M, Luker TJ, Mortimore MM, Pimm AD, Riley RJ, Roberts N, Robertson M, Theaker J, Thorne PV, Weaver R, Webborn P, Willis P. Furber M, et al. J Med Chem. 2007 Nov 29;50(24):5882-5. doi: 10.1021/jm700949w. Epub 2007 Oct 27. J Med Chem. 2007. PMID: 17963373
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