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83 results
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3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity.
Wedge SR, Porteous JK, Newlands ES. Wedge SR, et al. Br J Cancer. 1996 Oct;74(7):1030-6. doi: 10.1038/bjc.1996.485. Br J Cancer. 1996. PMID: 8855970 Free PMC article.
Use of dynamic contrast-enhanced MRI to evaluate acute treatment with ZD6474, a VEGF signalling inhibitor, in PC-3 prostate tumours.
Checkley D, Tessier JJ, Kendrew J, Waterton JC, Wedge SR. Checkley D, et al. Among authors: wedge sr. Br J Cancer. 2003 Nov 17;89(10):1889-95. doi: 10.1038/sj.bjc.6601386. Br J Cancer. 2003. PMID: 14612898 Free PMC article.
ZD6474--a novel inhibitor of VEGFR and EGFR tyrosine kinase activity.
Ryan AJ, Wedge SR. Ryan AJ, et al. Among authors: wedge sr. Br J Cancer. 2005 Jun;92 Suppl 1(Suppl 1):S6-13. doi: 10.1038/sj.bjc.6602603. Br J Cancer. 2005. PMID: 15928657 Free PMC article. Review.
Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel.
Hancox U, Cosulich S, Hanson L, Trigwell C, Lenaghan C, Ellston R, Dry H, Crafter C, Barlaam B, Fitzek M, Smith PD, Ogilvie D, D'Cruz C, Castriotta L, Wedge SR, Ward L, Powell S, Lawson M, Davies BR, Harrington EA, Foster E, Cumberbatch M, Green S, Barry ST. Hancox U, et al. Among authors: wedge sr. Mol Cancer Ther. 2015 Jan;14(1):48-58. doi: 10.1158/1535-7163.MCT-14-0406. Epub 2014 Nov 14. Mol Cancer Ther. 2015. PMID: 25398829
Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.
Alferez D, Wilkinson RW, Watkins J, Poulsom R, Mandir N, Wedge SR, Pyrah IT, Smith NR, Jackson L, Ryan AJ, Goodlad RA. Alferez D, et al. Among authors: wedge sr. Mol Cancer Ther. 2008 Mar;7(3):590-8. doi: 10.1158/1535-7163.MCT-07-0433. Mol Cancer Ther. 2008. PMID: 18347145
Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.
Senra JM, Telfer BA, Cherry KE, McCrudden CM, Hirst DG, O'Connor MJ, Wedge SR, Stratford IJ. Senra JM, et al. Among authors: wedge sr. Mol Cancer Ther. 2011 Oct;10(10):1949-58. doi: 10.1158/1535-7163.MCT-11-0278. Epub 2011 Aug 8. Mol Cancer Ther. 2011. PMID: 21825006 Free PMC article.
Anti-tumour and anti-vascular effects of cediranib (AZD2171) alone and in combination with other anti-tumour therapies.
Kendrew J, Odedra R, Logié A, Taylor PJ, Pearsall S, Ogilvie DJ, Wedge SR, Jürgensmeier JM. Kendrew J, et al. Among authors: wedge sr. Cancer Chemother Pharmacol. 2013 Apr;71(4):1021-32. doi: 10.1007/s00280-013-2097-x. Epub 2013 Jan 26. Cancer Chemother Pharmacol. 2013. PMID: 23355042
In vitro evaluation of temozolomide combined with X-irradiation.
Wedge SR, Porteous JK, Glaser MG, Marcus K, Newlands ES. Wedge SR, et al. Anticancer Drugs. 1997 Jan;8(1):92-7. doi: 10.1097/00001813-199701000-00013. Anticancer Drugs. 1997. PMID: 9147618
Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials.
Newlands ES, Stevens MF, Wedge SR, Wheelhouse RT, Brock C. Newlands ES, et al. Among authors: wedge sr. Cancer Treat Rev. 1997 Jan;23(1):35-61. doi: 10.1016/s0305-7372(97)90019-0. Cancer Treat Rev. 1997. PMID: 9189180 Review. No abstract available.
Phase I trial of temozolomide using an extended continuous oral schedule.
Brock CS, Newlands ES, Wedge SR, Bower M, Evans H, Colquhoun I, Roddie M, Glaser M, Brampton MH, Rustin GJ. Brock CS, et al. Among authors: wedge sr. Cancer Res. 1998 Oct 1;58(19):4363-7. Cancer Res. 1998. PMID: 9766665 Clinical Trial.
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