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Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2.
Weedon MN, Gloyn AL, Frayling TM, Hattersley AT, Davey Smith G, Ben-Shlomo Y. Weedon MN, et al. Diabetologia. 2003 Jul;46(7):1021-3. doi: 10.1007/s00125-003-1135-3. Epub 2003 Jun 18. Diabetologia. 2003. PMID: 12819904 No abstract available.
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM. Gloyn AL, et al. Among authors: weedon mn. Diabetes. 2003 Feb;52(2):568-72. doi: 10.2337/diabetes.52.2.568. Diabetes. 2003. PMID: 12540637
Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
Patel S, Minton JA, Weedon MN, Frayling TM, Ricketts C, Hitman GA, McCarthy MI, Hattersley AT, Walker M, Barrett TG. Patel S, et al. Among authors: weedon mn. Diabetologia. 2006 Jun;49(6):1209-13. doi: 10.1007/s00125-006-0227-2. Epub 2006 Apr 7. Diabetologia. 2006. PMID: 16601972
Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.
Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M; RISC Consortium. Pascoe L, et al. Among authors: weedon mn. Diabetologia. 2008 Nov;51(11):1989-92. doi: 10.1007/s00125-008-1124-7. Epub 2008 Aug 22. Diabetologia. 2008. PMID: 18719881
Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, Scott LJ; DIAGRAM Consortium, Palmer CN, Morris AD, McCarthy MI, Ferrucci L, Hattersley AT, Zeggini E, Frayling TM. Rafiq S, et al. Among authors: weedon mn. Diabetologia. 2008 Dec;51(12):2205-13. doi: 10.1007/s00125-008-1160-3. Epub 2008 Oct 14. Diabetologia. 2008. PMID: 18853133 Free PMC article.
FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.
Yajnik CS, Janipalli CS, Bhaskar S, Kulkarni SR, Freathy RM, Prakash S, Mani KR, Weedon MN, Kale SD, Deshpande J, Krishnaveni GV, Veena SR, Fall CH, McCarthy MI, Frayling TM, Hattersley AT, Chandak GR. Yajnik CS, et al. Among authors: weedon mn. Diabetologia. 2009 Feb;52(2):247-52. doi: 10.1007/s00125-008-1186-6. Epub 2008 Nov 13. Diabetologia. 2009. PMID: 19005641 Free PMC article.
The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.
Webster RJ, Warrington NM, Weedon MN, Hattersley AT, McCaskie PA, Beilby JP, Palmer LJ, Frayling TM. Webster RJ, et al. Among authors: weedon mn. Diabetologia. 2009 Jan;52(1):106-14. doi: 10.1007/s00125-008-1175-9. Epub 2008 Nov 19. Diabetologia. 2009. PMID: 19018513
Circulating beta-carotene levels and type 2 diabetes-cause or effect?
Perry JR, Ferrucci L, Bandinelli S, Guralnik J, Semba RD, Rice N, Melzer D; DIAGRAM Consortium, Saxena R, Scott LJ, McCarthy MI, Hattersley AT, Zeggini E, Weedon MN, Frayling TM. Perry JR, et al. Among authors: weedon mn. Diabetologia. 2009 Oct;52(10):2117-21. doi: 10.1007/s00125-009-1475-8. Epub 2009 Aug 7. Diabetologia. 2009. PMID: 19662379 Free PMC article.
Genetic association analysis of LARS2 with type 2 diabetes.
Reiling E, Jafar-Mohammadi B, van 't Riet E, Weedon MN, van Vliet-Ostaptchouk JV, Hansen T, Saxena R, van Haeften TW, Arp PA, Das S, Nijpels G, Groenewoud MJ, van Hove EC, Uitterlinden AG, Smit JW, Morris AD, Doney AS, Palmer CN, Guiducci C, Hattersley AT, Frayling TM, Pedersen O, Slagboom PE, Altshuler DM, Groop L, Romijn JA, Maassen JA, Hofker MH, Dekker JM, McCarthy MI, 't Hart LM. Reiling E, et al. Among authors: weedon mn. Diabetologia. 2010 Jan;53(1):103-10. doi: 10.1007/s00125-009-1557-7. Epub 2009 Oct 22. Diabetologia. 2010. PMID: 19847392 Free PMC article.
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.
Jafar-Mohammadi B, Groves CJ, Gjesing AP, Herrera BM, Winckler W, Stringham HM, Morris AP, Lauritzen T, Doney AS, Morris AD, Weedon MN, Swift AJ, Kuusisto J, Laakso M, Altshuler D, Hattersley AT, Collins FS, Boehnke M, Hansen T, Pedersen O, Palmer CN, Frayling TM; DIAGRAM Consortium, Gloyn AL, McCarthy MI. Jafar-Mohammadi B, et al. Among authors: weedon mn. Diabetologia. 2011 Jan;54(1):111-9. doi: 10.1007/s00125-010-1916-4. Epub 2010 Sep 29. Diabetologia. 2011. PMID: 20878384 Free PMC article.
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