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Non-targeted Tracer Fate Detection.
Weindl D, Wegner A, Hiller K. Weindl D, et al. Among authors: wegner a. Methods Enzymol. 2015;561:277-302. doi: 10.1016/bs.mie.2015.04.003. Epub 2015 Jun 14. Methods Enzymol. 2015. PMID: 26358908 Review.
Only recently non-targeted stable isotope labeling approaches have emerged as a powerful tool to gain insights into metabolism. However, the manual detection of isotopic enrichment for a non-targeted analysis is tedious and time consuming. To overcome this limitatio …
Only recently non-targeted stable isotope labeling approaches have emerged as a powerful tool to gain insights into metabolism. Howev …
Fragment formula calculator (FFC): determination of chemical formulas for fragment ions in mass spectrometric data.
Wegner A, Weindl D, Jäger C, Sapcariu SC, Dong X, Stephanopoulos G, Hiller K. Wegner A, et al. Anal Chem. 2014 Feb 18;86(4):2221-8. doi: 10.1021/ac403879d. Epub 2014 Feb 5. Anal Chem. 2014. PMID: 24498896 Free PMC article.
Moreover, the positional distribution of stable isotopes within a fragment ion is of high interest for stable isotope-assisted metabolomics techniques. ...For that reason, we developed an algorithm, based on a systematic bond cleavage, to determine chemical formulas …
Moreover, the positional distribution of stable isotopes within a fragment ion is of high interest for stable isotope-assisted metabo …
NTFD--a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data.
Hiller K, Wegner A, Weindl D, Cordes T, Metallo CM, Kelleher JK, Stephanopoulos G. Hiller K, et al. Among authors: wegner a. Bioinformatics. 2013 May 1;29(9):1226-8. doi: 10.1093/bioinformatics/btt119. Epub 2013 Mar 11. Bioinformatics. 2013. PMID: 23479350 Free PMC article.
Here, we present NTFD (non-targeted tracer fate detection), a software for the non-targeted analysis of all detectable compounds derived from a stable isotope-labeled tracer present in a GC/MS dataset. ...These data provide information on relative fluxes in …
Here, we present NTFD (non-targeted tracer fate detection), a software for the non-targeted analysis of all detectable compounds deri …
Isotope cluster-based compound matching in gas chromatography/mass spectrometry for non-targeted metabolomics.
Wegner A, Sapcariu SC, Weindl D, Hiller K. Wegner A, et al. Anal Chem. 2013 Apr 16;85(8):4030-7. doi: 10.1021/ac303774z. Epub 2013 Apr 5. Anal Chem. 2013. PMID: 23514283
Gas chromatography coupled to mass spectrometry (GC/MS) has emerged as a powerful tool in metabolomics studies. A major bottleneck in current data analysis of GC/MS-based metabolomics studies is compound matching and identification, as current methods generate high …
Gas chromatography coupled to mass spectrometry (GC/MS) has emerged as a powerful tool in metabolomics studies. A major bottle …
MIA: non-targeted mass isotopolome analysis.
Weindl D, Wegner A, Hiller K. Weindl D, et al. Among authors: wegner a. Bioinformatics. 2016 Sep 15;32(18):2875-6. doi: 10.1093/bioinformatics/btw317. Epub 2016 Jun 6. Bioinformatics. 2016. PMID: 27273671 Free PMC article.
MIA detects and visualizes isotopic enrichment in gas chromatography electron ionization mass spectrometry (GC-EI-MS) datasets in a non-targeted manner. ...AVAILABILITY AND IMPLEMENTATION: Linux and Windows binaries, documentation, and sample data are freely available for …
MIA detects and visualizes isotopic enrichment in gas chromatography electron ionization mass spectrometry (GC-EI-MS) datasets in a n …
Isotopologue ratio normalization for non-targeted metabolomics.
Weindl D, Wegner A, Jäger C, Hiller K. Weindl D, et al. Among authors: wegner a. J Chromatogr A. 2015 Apr 10;1389:112-9. doi: 10.1016/j.chroma.2015.02.025. Epub 2015 Feb 17. J Chromatogr A. 2015. PMID: 25748542
For targeted analyses isotope dilution mass spectrometry is used to provide a robust normalization reference. Here, we present an approach that allows for the automated semi-quantification of metabolites relative to a fully stable isotope-labeled metabolite extract. …
For targeted analyses isotope dilution mass spectrometry is used to provide a robust normalization reference. Here, we present an app …
Analysis of mitochondrial metabolism in situ: Combining stable isotope labeling with selective permeabilization.
Nonnenmacher Y, Palorini R, d'Herouël AF, Krämer L, Neumann-Schaal M, Chiaradonna F, Skupin A, Wegner A, Hiller K. Nonnenmacher Y, et al. Among authors: wegner a. Metab Eng. 2017 Sep;43(Pt B):147-155. doi: 10.1016/j.ymben.2016.12.005. Epub 2016 Dec 15. Metab Eng. 2017. PMID: 27988388
To date, it is well-established that mitochondrial dysfunction does not only play a vital role in cancer but also in other pathological conditions such as neurodegenerative diseases and inflammation. ...
To date, it is well-established that mitochondrial dysfunction does not only play a vital role in cancer but also in other pathologic …
Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis.
Weindl D, Cordes T, Battello N, Sapcariu SC, Dong X, Wegner A, Hiller K. Weindl D, et al. Among authors: wegner a. Cancer Metab. 2016 Apr 23;4:10. doi: 10.1186/s40170-016-0150-z. eCollection 2016. Cancer Metab. 2016. PMID: 27110360 Free PMC article.
RESULTS: We present a novel workflow to analyze non-targeted metabolome-wide stable isotope labeling data to detect metabolic flux changes in a non-targeted manner. ...CONCLUSIONS: Differential stable isotope labeling analysis provides qualitative metabolic flux inf …
RESULTS: We present a novel workflow to analyze non-targeted metabolome-wide stable isotope labeling data to detect metabolic flux ch …
Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism.
Meiser J, Delcambre S, Wegner A, Jäger C, Ghelfi J, d'Herouel AF, Dong X, Weindl D, Stautner C, Nonnenmacher Y, Michelucci A, Popp O, Giesert F, Schildknecht S, Krämer L, Schneider JG, Woitalla D, Wurst W, Skupin A, Weisenhorn DM, Krüger R, Leist M, Hiller K. Meiser J, et al. Among authors: wegner a. Neurobiol Dis. 2016 May;89:112-25. doi: 10.1016/j.nbd.2016.01.019. Epub 2016 Feb 1. Neurobiol Dis. 2016. PMID: 26836693
The oncogene DJ-1 has been originally identified as a suppressor of PTEN. Further on, loss-of-function mutations have been described as a causative factor in Parkinson's disease (PD). ...Down-regulation of these pathways, as a result of loss of DJ-1 leads to …
The oncogene DJ-1 has been originally identified as a suppressor of PTEN. Further on, loss-of-function mutations have been described …
The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells.
Battello N, Zimmer AD, Goebel C, Dong X, Behrmann I, Haan C, Hiller K, Wegner A. Battello N, et al. Among authors: wegner a. Cancer Metab. 2016 Feb 17;4:3. doi: 10.1186/s40170-016-0141-0. eCollection 2016. Cancer Metab. 2016. PMID: 26889381 Free PMC article.
As a result of the impaired mitochondrial glucose and glutamine oxidation, the reductive isocitrate dehydrogenase flux was increased. CONCLUSIONS: We provide evidence that connects the inflammatory mediator OSM to a hypoxia-like metabolic phenotype. In the human hep …
As a result of the impaired mitochondrial glucose and glutamine oxidation, the reductive isocitrate dehydrogenase flux was increased. …
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