Wei-Shuo Fang - Search Results

Year	Number of Results
2002	2
2006	3
2007	3
2008	6
2009	8
2010	5
2011	2
2012	3
2013	2
2014	1
2015	1
2016	3
2017	4
2018	1
2019	4
2020	1
2022	3
2023	2
2026	1

1

Discovery of 7-ether substituted homoisoflavonoids as selective FXR modulators attenuating MASH via the FXR and AMPK pathways.

Zhang G, Jia W, Zhou X, Niu S, Wang N, Wang S, Wang M, Hu Y, Zhang N, Huan Y, Sun H, Liu J, He H, Fang WS. Zhang G, et al. Among authors: fang ws. Eur J Med Chem. 2026 Jul 5;311:118837. doi: 10.1016/j.ejmech.2026.118837. Epub 2026 Apr 6. Eur J Med Chem. 2026. PMID: 41950649

2

Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency.

Ma Y, Josa-Prado F, Essif JN, Liu S, Li S, Lucena-Agell D, Chan PY, Goossens K, Hortigüela R, Matesanz R, Wang Y, Gago F, Wang H, Risinger A, Diaz JF, Fang WS. Ma Y, et al. Among authors: fang ws. Eur J Med Chem. 2023 Nov 5;259:115668. doi: 10.1016/j.ejmech.2023.115668. Epub 2023 Jul 19. Eur J Med Chem. 2023. PMID: 37490800

3

Structural insight into the stabilization of microtubules by taxanes.

Prota AE, Lucena-Agell D, Ma Y, Estevez-Gallego J, Li S, Bargsten K, Josa-Prado F, Altmann KH, Gaillard N, Kamimura S, Mühlethaler T, Gago F, Oliva MA, Steinmetz MO, Fang WS, Díaz JF. Prota AE, et al. Among authors: fang ws. Elife. 2023 Mar 6;12:e84791. doi: 10.7554/eLife.84791. Elife. 2023. PMID: 36876916 Free PMC article.

4

Targeting the tubulin C-terminal tail by charged small molecules.

Li S, Mori M, Yang M, Elfazazi S, Hortigüela R, Chan P, Feng X, Risinger A, Yang Z, Oliva MÁ, Fernando Díaz J, Fang WS. Li S, et al. Among authors: fang ws. Org Biomol Chem. 2022 Dec 21;21(1):153-162. doi: 10.1039/d2ob01910h. Org Biomol Chem. 2022. PMID: 36472095

5

Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo.

Wang S, Huan Y, Niu S, Cao H, Yang M, Zhou X, Gao X, Wang X, Shen Z, Fang WS. Wang S, et al. Among authors: fang ws. Bioorg Chem. 2022 Dec;129:106203. doi: 10.1016/j.bioorg.2022.106203. Epub 2022 Oct 14. Bioorg Chem. 2022. PMID: 36265352

6

Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis.

Niu S, Zhang G, Wang N, Lv G, Liu J, Wang H, Fang WS. Niu S, et al. Among authors: fang ws. ChemMedChem. 2022 Jun 3;17(11):e202100778. doi: 10.1002/cmdc.202100778. Epub 2022 Apr 11. ChemMedChem. 2022. PMID: 35274459

7

Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties.

Sun DY, Cheng C, Moschke K, Huang J, Fang WS. Sun DY, et al. Among authors: fang ws. Molecules. 2019 Dec 26;25(1):102. doi: 10.3390/molecules25010102. Molecules. 2019. PMID: 31888099 Free PMC article.

8

Taxanes convert regions of perturbed microtubule growth into rescue sites.

Rai A, Liu T, Glauser S, Katrukha EA, Estévez-Gallego J, Rodríguez-García R, Fang WS, Díaz JF, Steinmetz MO, Altmann KH, Kapitein LC, Moores CA, Akhmanova A. Rai A, et al. Among authors: fang ws. Nat Mater. 2020 Mar;19(3):355-365. doi: 10.1038/s41563-019-0546-6. Epub 2019 Dec 9. Nat Mater. 2020. PMID: 31819210

9

Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR.

Fang WS, Sun DY, Yang S, Cheng C, Moschke K, Li T, Sun S, Lichtenthaler SF, Huang J, Wang Y. Fang WS, et al. Bioorg Chem. 2019 Nov;92:103253. doi: 10.1016/j.bioorg.2019.103253. Epub 2019 Sep 13. Bioorg Chem. 2019. PMID: 31557620

10

Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids.

Zhao Y, Wang TE, Mills A, Gago F, Fang WS. Zhao Y, et al. Among authors: fang ws. Molecules. 2019 Jun 8;24(11):2161. doi: 10.3390/molecules24112161. Molecules. 2019. PMID: 31181726 Free PMC article.

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