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Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial.
Messier SP, Mihalko SL, Legault C, Miller GD, Nicklas BJ, DeVita P, Beavers DP, Hunter DJ, Lyles MF, Eckstein F, Williamson JD, Carr JJ, Guermazi A, Loeser RF. Messier SP, et al. JAMA. 2013 Sep 25;310(12):1263-73. doi: 10.1001/jama.2013.277669. JAMA. 2013. PMID: 24065013 Free PMC article. Clinical Trial.
The diet and exercise interventions were center-based with options for the exercise groups to transition to a home-based program. Participants were 454 overweight and obese older community-dwelling adults (age 55 years with body mass index of 27-41) wi …
The diet and exercise interventions were center-based with options for the exercise groups to transition to a home-based program. Participan …
Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis.
Messier SP, Gutekunst DJ, Davis C, DeVita P. Messier SP, et al. Arthritis Rheum. 2005 Jul;52(7):2026-32. doi: 10.1002/art.21139. Arthritis Rheum. 2005. PMID: 15986358 Free article. Clinical Trial.
OBJECTIVE: To determine the relationship between change in body mass and knee-joint moments and forces during walking in overweight and obese older adults with knee osteoarthritis (OA) following an 18-month clinical trial of …
OBJECTIVE: To determine the relationship between change in body mass and knee-joint moments and forces during walking in ov
Weight loss changed gait kinematics in individuals with obesity and knee pain.
Li JS, Tsai TY, Clancy MM, Li G, Lewis CL, Felson DT. Li JS, et al. Gait Posture. 2019 Feb;68:461-465. doi: 10.1016/j.gaitpost.2018.12.031. Epub 2018 Dec 24. Gait Posture. 2019. PMID: 30611976 Free PMC article.
Weight loss reduces joint loads, and therefore potentially delays disease progression; however, how the knee joint responds to weight loss in individuals with obesity and knee pain is not clear. RESEARCH
Weight loss reduces joint loads, and therefore potentially delays disease progression; however, how the
Effects of an intensive weight loss program on knee joint loading in obese adults with knee osteoarthritis.
Aaboe J, Bliddal H, Messier SP, Alkjær T, Henriksen M. Aaboe J, et al. Osteoarthritis Cartilage. 2011 Jul;19(7):822-8. doi: 10.1016/j.joca.2011.03.006. Epub 2011 Apr 8. Osteoarthritis Cartilage. 2011. PMID: 21440076 Free article.
OBJECTIVE: To determine the effect of an intensive weight loss program on knee joint loads during walking in obese patients with knee osteoarthritis (OA). ...CONCLUSION: Weight loss is an excellent short-term i …
OBJECTIVE: To determine the effect of an intensive weight loss program on knee joint loads during walking …
Reductions in knee joint forces with weight loss are attenuated by gait adaptations in class III obesity.
DeVita P, Rider P, Hortobágyi T. DeVita P, et al. Gait Posture. 2016 Mar;45:25-30. doi: 10.1016/j.gaitpost.2015.12.040. Epub 2016 Jan 6. Gait Posture. 2016. PMID: 26979878
A consensus exists that high knee joint forces are a precursor to knee osteoarthritis and weight loss reduces these forces. ...The purpose was to determine the effects of weight loss on knee muscle and joint
A consensus exists that high knee joint forces are a precursor to knee osteoarthritis and weight loss
Bariatric surgery improves knee function and not knee pain in the early postoperative period.
Hamdi A, Albaghdadi AT, Ghalimah B, Alnowiser A, Ahmad A, Altaf A. Hamdi A, et al. J Orthop Surg Res. 2018 Apr 11;13(1):82. doi: 10.1186/s13018-018-0803-4. J Orthop Surg Res. 2018. PMID: 29642931 Free PMC article.
BACKGROUND: Obesity remains the strongest predictor of knee osteoarthritis (OA). Studies have reported improvement in knee pain and function post-bariatric surgery secondary to weight loss and reduced mechanical loading, yet …
BACKGROUND: Obesity remains the strongest predictor of knee osteoarthritis (OA). Studies have reported improvement in …
Tackling obesity in knee osteoarthritis.
Wluka AE, Lombard CB, Cicuttini FM. Wluka AE, et al. Nat Rev Rheumatol. 2013 Apr;9(4):225-35. doi: 10.1038/nrrheum.2012.224. Epub 2012 Dec 18. Nat Rev Rheumatol. 2013. PMID: 23247649 Review.
Obesity and knee osteoarthritis (OA), two of the most common chronic diseases, are often comorbid. ...Weight loss reduces the risk of incident knee OA, and, in established disease, reduces symptoms, improves function and is
Obesity and knee osteoarthritis (OA), two of the most common chronic diseases, are often comorbid. ...Weight
Obesity and osteoarthritis: disease genesis and nonpharmacologic weight management.
Messier SP. Messier SP. Rheum Dis Clin North Am. 2008 Aug;34(3):713-29. doi: 10.1016/j.rdc.2008.04.007. Rheum Dis Clin North Am. 2008. PMID: 18687279 Free PMC article. Review.
The mechanisms by which obesity affects osteoarthritis (OA) are of great concern to osteoarthritis researchers and clinicians who manage this disease. ...This article reviews the physiologic and mechanical consequences of obesity in older adu
The mechanisms by which obesity affects osteoarthritis (OA) are of great concern to osteoarthritis researchers and clin …
Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial.
Henriksen M, Hunter DJ, Dam EB, Messier SP, Andriacchi TP, Lohmander LS, Aaboe J, Boesen M, Gudbergsen H, Bliddal H, Christensen R. Henriksen M, et al. Osteoarthritis Cartilage. 2013 Dec;21(12):1865-75. doi: 10.1016/j.joca.2013.10.003. Epub 2013 Oct 14. Osteoarthritis Cartilage. 2013. PMID: 24135273 Free article. Clinical Trial.
METHODS: Data from a prospective study of weight loss in obese patients with knee OA (the CARtilage in obese knee OsteoarThritis (CAROT) study) were used to determine changes in knee joint compressive loadings
METHODS: Data from a prospective study of weight loss in obese patients with knee OA (the CARtilage in obese
The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale.
Messier SP, Legault C, Mihalko S, Miller GD, Loeser RF, DeVita P, Lyles M, Eckstein F, Hunter DJ, Williamson JD, Nicklas BJ. Messier SP, et al. BMC Musculoskelet Disord. 2009 Jul 28;10:93. doi: 10.1186/1471-2474-10-93. BMC Musculoskelet Disord. 2009. PMID: 19638215 Free PMC article. Clinical Trial.
We are currently conducting a study to test the hypothesis that intensive weight loss will reduce inflammation and joint loads sufficiently to alter disease progression, either with or without exercise. ...METHODS/DESIGN: This is a prospective, …
We are currently conducting a study to test the hypothesis that intensive weight loss will reduce inflammation and j