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Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.
Schmidt LS, Thomsen M, Weikop P, Dencker D, Wess J, Woldbye DP, Wortwein G, Fink-Jensen A. Schmidt LS, et al. Among authors: Weikop P. Psychopharmacology (Berl). 2011 Aug;216(3):367-78. doi: 10.1007/s00213-011-2225-4. Epub 2011 Mar 5. Psychopharmacology (Berl). 2011. PMID: 21373792 Free PMC article.
The role of alpha1- and alpha2-adrenoreceptors on venlafaxine-induced elevation of extracellular serotonin, noradrenaline and dopamine levels in the rat prefrontal cortex and hippocampus.
Weikop P, Kehr J, Scheel-Krüger J. Weikop P, et al. J Psychopharmacol. 2004 Sep;18(3):395-403. doi: 10.1177/026988110401800311. J Psychopharmacol. 2004. PMID: 15358984
The mixed 5-HT and NA reuptake inhibitor venlafaxine (10 mg/kg, i.p.) increased the efflux of 5-HT, NA and DA almost equally, to approximately 200% of the control levels in the PFC. ...
The mixed 5-HT and NA reuptake inhibitor venlafaxine (10 mg/kg, i.p.) increased the efflux of 5-HT, NA and DA almost equally, to appr …
Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels.
Reddy IA, Pino JA, Weikop P, Osses N, Sørensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A. Reddy IA, et al. Among authors: Weikop P. Transl Psychiatry. 2016 May 17;6(5):e809. doi: 10.1038/tp.2016.86. Transl Psychiatry. 2016. PMID: 27187231 Free PMC article.
Differential effects of adjunctive methylphenidate and citalopram on extracellular levels of serotonin, noradrenaline and dopamine in the rat brain.
Weikop P, Yoshitake T, Kehr J. Weikop P, et al. Eur Neuropsychopharmacol. 2007 Oct;17(10):658-71. doi: 10.1016/j.euroneuro.2007.02.014. Epub 2007 Mar 26. Eur Neuropsychopharmacol. 2007. PMID: 17383162
Administration of methylphenidate (2.5 mg/kg s.c.) with citalopram (5 mg/kg i.p.) compared to methylphenidate alone caused a marked enhancement of dopamine levels in the prefrontal cortex, n. accumbens and hippocampus, but not in the striatum. ...
Administration of methylphenidate (2.5 mg/kg s.c.) with citalopram (5 mg/kg i.p.) compared to methylphenidate alone caused a marked e …
Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan.
Jacobsen JP, Nielsen EØ, Hummel R, Redrobe JP, Mirza N, Weikop P. Jacobsen JP, et al. Among authors: Weikop P. Psychopharmacology (Berl). 2008 Aug;199(2):137-50. doi: 10.1007/s00213-008-1142-7. Epub 2008 May 22. Psychopharmacology (Berl). 2008. PMID: 18496675
The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine.
Hansen HH, Andreasen JT, Weikop P, Mirza N, Scheel-Krüger J, Mikkelsen JD. Hansen HH, et al. Among authors: Weikop P. Eur J Pharmacol. 2007 Sep 10;570(1-3):77-88. doi: 10.1016/j.ejphar.2007.05.029. Epub 2007 Jun 5. Eur J Pharmacol. 2007. PMID: 17628530
Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline.
Dencker D, Wörtwein G, Weikop P, Jeon J, Thomsen M, Sager TN, Mørk A, Woldbye DP, Wess J, Fink-Jensen A. Dencker D, et al. Among authors: Weikop P. J Neurosci. 2011 Apr 20;31(16):5905-8. doi: 10.1523/JNEUROSCI.0370-11.2011. J Neurosci. 2011. PMID: 21508215 Free PMC article.
Reciprocal effects of combined administration of serotonin, noradrenaline and dopamine reuptake inhibitors on serotonin and dopamine levels in the rat prefrontal cortex: the role of 5-HT1A receptors.
Weikop P, Kehr J, Scheel-Krüger J. Weikop P, et al. J Psychopharmacol. 2007 Nov;21(8):795-804. doi: 10.1177/0269881107077347. J Psychopharmacol. 2007. PMID: 17984160
At the highest dose tested, adjunctive methylphenidate (10 mg/kg s.c.) to citalopram markedly attenuated by 63% the extracellular levels of 5-HT as compared to the levels induced by citalopram (5 mg/kg i.p.) alone, whereas the overall DA concentrations significantly increased to about 149% of those induced by methylphenidate alone. Similarly, the combination of venlafaxine with GBR12909 (10 mg/kg s.c.) caused a reduction of 5-HT levels to 66% of the levels induced by venlafaxine (10 mg/kg i.p.) alone, whereas the overall DA levels increased to 151% of the venlafaxine-treated group. ...
At the highest dose tested, adjunctive methylphenidate (10 mg/kg s.c.) to citalopram markedly attenuated by 63% the extracellular levels of …
Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus.
Kornum BR, Weikop P, Moller A, Ronn LC, Knudsen GM, Aznar S. Kornum BR, et al. Among authors: Weikop P. Brain Res. 2006 Feb 16;1073-1074:262-8. doi: 10.1016/j.brainres.2005.12.030. Epub 2006 Jan 19. Brain Res. 2006. PMID: 16426583
For this purpose, neuronal activity was measured in rats with rivastigmine-induced elevated ACh levels after a 95% 5-HT depletion obtained by dosing p-chlorophenylalanine followed by D,L-fenfluramine. ...
For this purpose, neuronal activity was measured in rats with rivastigmine-induced elevated ACh levels after a 95% 5-HT depletion obtained b …
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