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Grignard-mediated synthesis and preliminary biological evaluation of novel 3-substituted farnesyl diphosphate analogues.
Zahn TJ, Weinbaum C, Gibbs RA. Zahn TJ, et al. Among authors: weinbaum c. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1763-6. doi: 10.1016/s0960-894x(00)00337-1. Bioorg Med Chem Lett. 2000. PMID: 10937743
Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I.
Zahn TJ, Whitney J, Weinbaum C, Gibbs RA. Zahn TJ, et al. Among authors: weinbaum c. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1605-8. doi: 10.1016/s0960-894x(01)00292-x. Bioorg Med Chem Lett. 2001. PMID: 11412990
A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity.
Peterson YK, Kelly P, Weinbaum CA, Casey PJ. Peterson YK, et al. J Biol Chem. 2006 May 5;281(18):12445-50. doi: 10.1074/jbc.M600168200. Epub 2006 Mar 3. J Biol Chem. 2006. PMID: 16517596
Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis.
Hightower KE, De S, Weinbaum C, Spence RA, Casey PJ. Hightower KE, et al. Among authors: weinbaum c. Biochem J. 2001 Dec 15;360(Pt 3):625-31. doi: 10.1042/0264-6021:3600625. Biochem J. 2001. PMID: 11736652 Free PMC article.
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.
Sjogren AK, Andersson KM, Liu M, Cutts BA, Karlsson C, Wahlstrom AM, Dalin M, Weinbaum C, Casey PJ, Tarkowski A, Swolin B, Young SG, Bergo MO. Sjogren AK, et al. Among authors: weinbaum c. J Clin Invest. 2007 May;117(5):1294-304. doi: 10.1172/JCI30868. J Clin Invest. 2007. PMID: 17476360 Free PMC article.
Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.
Ugolev Y, Berdichevsky Y, Weinbaum C, Pick E. Ugolev Y, et al. Among authors: weinbaum c. J Biol Chem. 2008 Aug 8;283(32):22257-71. doi: 10.1074/jbc.M800734200. Epub 2008 May 27. J Biol Chem. 2008. PMID: 18505730 Free PMC article.
We reported that liposomes containing high concentrations of monovalent anionic phospholipids cause Rac.RhoGDI complex dissociation ( Ugolev, Y., Molshanski-Mor, S., Weinbaum, C., and Pick, E. (2006) J. Biol. Chem. 281, 19204-19219 ). ...
We reported that liposomes containing high concentrations of monovalent anionic phospholipids cause Rac.RhoGDI complex dissociation ( Ugolev …
Liposomes comprising anionic but not neutral phospholipids cause dissociation of Rac(1 or 2) x RhoGDI complexes and support amphiphile-independent NADPH oxidase activation by such complexes.
Ugolev Y, Molshanski-Mor S, Weinbaum C, Pick E. Ugolev Y, et al. Among authors: weinbaum c. J Biol Chem. 2006 Jul 14;281(28):19204-19. doi: 10.1074/jbc.M600042200. Epub 2006 May 15. J Biol Chem. 2006. PMID: 16702219
Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras.
Sarfstein R, Gorzalczany Y, Mizrahi A, Berdichevsky Y, Molshanski-Mor S, Weinbaum C, Hirshberg M, Dagher MC, Pick E. Sarfstein R, et al. Among authors: weinbaum c. J Biol Chem. 2004 Apr 16;279(16):16007-16. doi: 10.1074/jbc.M312394200. Epub 2004 Feb 3. J Biol Chem. 2004. PMID: 14761978
A prenylated p67phox-Rac1 chimera elicits NADPH-dependent superoxide production by phagocyte membranes in the absence of an activator and of p47phox: conversion of a pagan NADPH oxidase to monotheism.
Gorzalczany Y, Alloul N, Sigal N, Weinbaum C, Pick E. Gorzalczany Y, et al. Among authors: weinbaum c. J Biol Chem. 2002 May 24;277(21):18605-10. doi: 10.1074/jbc.M202114200. Epub 2002 Mar 14. J Biol Chem. 2002. PMID: 11896062
The guanine nucleotide exchange factor trio activates the phagocyte NADPH oxidase in the absence of GDP to GTP exchange on Rac. "The emperor's nw clothes".
Sigal N, Gorzalczany Y, Sarfstein R, Weinbaum C, Zheng Y, Pick E. Sigal N, et al. Among authors: weinbaum c. J Biol Chem. 2003 Feb 14;278(7):4854-61. doi: 10.1074/jbc.M211011200. Epub 2002 Dec 9. J Biol Chem. 2003. PMID: 12475976
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