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RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response.
Penn-Nicholson A, Mbandi SK, Thompson E, Mendelsohn SC, Suliman S, Chegou NN, Malherbe ST, Darboe F, Erasmus M, Hanekom WA, Bilek N, Fisher M, Kaufmann SHE, Winter J, Murphy M, Wood R, Morrow C, Van Rhijn I, Moody B, Murray M, Andrade BB, Sterling TR, Sutherland J, Naidoo K, Padayatchi N, Walzl G, Hatherill M, Zak D, Scriba TJ; Adolescent Cohort Study team; GC6-74 Consortium; SATVI Clinical and Laboratory Team; ScreenTB Consortium; AE-TBC Consortium; RePORT Brazil Team; Peruvian Household Contacts Cohort Team; CAPRISA IMPRESS team. Penn-Nicholson A, et al. Sci Rep. 2020 May 25;10(1):8629. doi: 10.1038/s41598-020-65043-8. Sci Rep. 2020. PMID: 32451443 Free PMC article.
Author Correction: The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis.
Lozza L, Moura-Alves P, Domaszewska T, Crespo CL, Streata I, Kreuchwig A, Puyskens A, Bechtle M, Klemm M, Zedler U, Ungureanu BS, Guhlich-Bornhof U, Koehler AB, Stäber M, Mollenkopf HJ, Hurwitz R, Furkert J, Krause G, Weiner J 3rd, Jacinto A, Mihai I, Leite-de-Moraes M, Siebenhaar F, Maurer M, Kaufmann SHE. Lozza L, et al. Among authors: weiner j 3rd. Sci Rep. 2020 May 20;10(1):8640. doi: 10.1038/s41598-020-65510-2. Sci Rep. 2020. PMID: 32433586 Free PMC article.
FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity.
Krishnamoorthy G, Kaiser P, Abu Abed U, Weiner J 3rd, Moura-Alves P, Brinkmann V, Kaufmann SHE. Krishnamoorthy G, et al. Among authors: weiner j 3rd. Dis Model Mech. 2020 Mar 30;13(3):dmm041954. doi: 10.1242/dmm.041954. Dis Model Mech. 2020. PMID: 32034005 Free PMC article.
Host monitoring of quorum sensing during Pseudomonas aeruginosa infection.
Moura-Alves P, Puyskens A, Stinn A, Klemm M, Guhlich-Bornhof U, Dorhoi A, Furkert J, Kreuchwig A, Protze J, Lozza L, Pei G, Saikali P, Perdomo C, Mollenkopf HJ, Hurwitz R, Kirschhoefer F, Brenner-Weiss G, Weiner J 3rd, Oschkinat H, Kolbe M, Krause G, Kaufmann SHE. Moura-Alves P, et al. Among authors: weiner j 3rd. Science. 2019 Dec 20;366(6472):eaaw1629. doi: 10.1126/science.aaw1629. Science. 2019. PMID: 31857448
The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis.
Lozza L, Moura-Alves P, Domaszewska T, Lage Crespo C, Streata I, Kreuchwig A, Puyskens A, Bechtle M, Klemm M, Zedler U, Silviu Ungureanu B, Guhlich-Bornhof U, Koehler AB, Stäber M, Mollenkopf HJ, Hurwitz R, Furkert J, Krause G, Weiner J 3rd, Jacinto A, Mihai I, Leite-de-Moraes M, Siebenhaar F, Maurer M, Kaufmann SHE. Lozza L, et al. Among authors: weiner j 3rd. Sci Rep. 2019 Jul 26;9(1):10878. doi: 10.1038/s41598-019-47350-x. Sci Rep. 2019. PMID: 31350436 Free PMC article.
Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome.
Duffy FJ, Weiner J 3rd, Hansen S, Tabb DL, Suliman S, Thompson E, Maertzdorf J, Shankar S, Tromp G, Parida S, Dover D, Axthelm MK, Sutherland JS, Dockrell HM, Ottenhoff THM, Scriba TJ, Picker LJ, Walzl G, Kaufmann SHE, Zak DE; GC6-74 Consortium. Duffy FJ, et al. Among authors: weiner j 3rd. Front Immunol. 2019 Mar 22;10:527. doi: 10.3389/fimmu.2019.00527. eCollection 2019. Front Immunol. 2019. PMID: 30967866 Free PMC article.
Metabolite changes in blood predict the onset of tuberculosis.
Weiner J 3rd, Maertzdorf J, Sutherland JS, Duffy FJ, Thompson E, Suliman S, McEwen G, Thiel B, Parida SK, Zyla J, Hanekom WA, Mohney RP, Boom WH, Mayanja-Kizza H, Howe R, Dockrell HM, Ottenhoff THM, Scriba TJ, Zak DE, Walzl G, Kaufmann SHE; GC6-74 consortium. Weiner J 3rd, et al. Nat Commun. 2018 Dec 6;9(1):5208. doi: 10.1038/s41467-018-07635-7. Nat Commun. 2018. PMID: 30523338 Free PMC article. Clinical Trial.
The potential of metabolic profiling for vaccine development.
Weiner J 3rd, Mohney RP, Kaufmann SHE. Weiner J 3rd, et al. Semin Immunol. 2018 Oct;39:44-51. doi: 10.1016/j.smim.2018.07.002. Epub 2018 Jul 19. Semin Immunol. 2018. PMID: 30033150 Review.
A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts.
Duffy FJ, Thompson E, Downing K, Suliman S, Mayanja-Kizza H, Boom WH, Thiel B, Weiner Iii J, Kaufmann SHE, Dover D, Tabb DL, Dockrell HM, Ottenhoff THM, Tromp G, Scriba TJ, Zak DE, Walzl G; GC6-74 Consortium. Duffy FJ, et al. Front Immunol. 2018 Apr 13;9:661. doi: 10.3389/fimmu.2018.00661. eCollection 2018. Front Immunol. 2018. PMID: 29706954 Free PMC article.
Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis.
Suliman S, Thompson EG, Sutherland J, Weiner J 3rd, Ota MOC, Shankar S, Penn-Nicholson A, Thiel B, Erasmus M, Maertzdorf J, Duffy FJ, Hill PC, Hughes EJ, Stanley K, Downing K, Fisher ML, Valvo J, Parida SK, van der Spuy G, Tromp G, Adetifa IMO, Donkor S, Howe R, Mayanja-Kizza H, Boom WH, Dockrell HM, Ottenhoff THM, Hatherill M, Aderem A, Hanekom WA, Scriba TJ, Kaufmann SHE, Zak DE, Walzl G; GC6-74 cohort study team, The ACS cohort study team. Suliman S, et al. Among authors: weiner j 3rd. Am J Respir Crit Care Med. 2018 May 1;197(9):1198-1208. doi: 10.1164/rccm.201711-2340OC. Am J Respir Crit Care Med. 2018. PMID: 29624071 Free PMC article.
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